Melanie S. Hulshoff

High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenuates renal fibrosis

Xingbo Xu, Xiao-Ying Tan, Björn Tampe et al. · Nature Communications · 2018 · 145 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +17

Serelaxin alleviates cardiac fibrosis through inhibiting endothelial-to-mesenchymal transition via RXFP1

Tim Wilhelmi, Xingbo Xu, Xiao-Ying Tan et al. · Theranostics · 2020 · 55 citations · Full text

Medicine, Cardiology, Pharmacology +12

Vedolizumab to prevent postoperative recurrence of Crohn's disease (REPREVIO): a multicentre, double-blind, randomised, placebo-controlled trial

Geert D’Haens, Carlos Taxonera, Antonio López–Sanromán et al. · ˜The œLancet. Gastroenterology & hepatology · 2024 · 37 citations · Full text

Medicine, Pharmacotherapy, Surgery +10

miR-132-3p and KLF7 as novel regulators of aortic stiffening-associated EndMT in type 2 diabetes mellitus

Melanie S. Hulshoff, Isabel N. Schellinger, Xingbo Xu et al. · Diabetology & Metabolic Syndrome · 2023 · 20 citations · Full text

Life Sciences, Endocrinology, Molecular Biology +13

Development and validation of peripheral blood DNA methylation signatures to predict response to biological therapy in adults with Crohn's disease (EPIC-CD): an epigenome-wide association study

V Joustra, Andrew Y. F. Li Yim, Peter Henneman et al. · ˜The œLancet. Gastroenterology & hepatology · 2025 · 14 citations · Full text

Life Sciences, Immunology, Molecular Biology +16