The design of novel materials to use simultaneously in an ocular system for driven therapeutics and wound healing is still challenging. Here, we produced nanocomposites of tungsten disulfide carriers with spherical cobalt ferrite nanoparticles (NPs) as core inside a cubic iron oxide NPs shell (WS₂/s-CoFe₂O₄@c-Fe₃O₄). Transmission electron microscopy (TEM) confirmed that 10 nm s-CoFe₂O₄@c-Fe₃O₄ NPs were attached on the WS₂ sheet surfaces. The cytotoxicity of the WS₂ sheets and nanocomposites were evaluated on bovine cornea endothelial cells (BCECs) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for a duration of three days. The MTT assay results showed low toxicity of the WS₂ sheets on BCECs by 67% cell viability at 100 μg/mL in 24 h, while the nanocomposites show 50% cell viability in the same conditions. The magnetic resonance imaging (MRI) of nanocomposites revealed the excellent T₂-weighted imaging with an r₂ contrast of 108 mM^-1 S^-1. The in vitro photothermal therapy based on WS₂ sheets and WS₂/s-CoFe₂O₄ @c-Fe₃O₄ nanocomposites using 808 nm laser showed that the maximum thermal energy dispatched in medium at different applied power densities (1200 mw, 1800, 2200, 2600 mW) was for 0.1 mg/mL of the sample solution. The migration assay of BCECs showed that the wound healing was approximately 20% slower for the cell exposed by nanocomposites compared with the control (no exposed BCECs). We believe that WS₂/s-CoFe₂O₄@c-Fe₃O₄ nanocomposites have a synergic effect as photothermal therapy agents for eye diseases and could be a target in an ocular system using MRI.

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