Carmen Wheatley

A scarlet pimpernel for the resolution of inflammation? The role of supra-therapeutic doses of cobalamin, in the treatment of systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, and septic or traumatic shock

Carmen Wheatley · Medical Hypotheses · 2006 · 59 citations

Veterinary Medicine, Pharmacology, Pharmacotherapy +17

The return of the Scarlet Pimpernel: cobalamin in inflammation II — cobalamins can both selectively promote all three nitric oxide synthases (NOS), particularly iNOS and eNOS, and, as needed, selectively inhibit iNOS and nNOS

Carmen Wheatley · Journal of Nutritional & Environmental Medicine · 2007 · 38 citations · Full text

Life Sciences, Biochemistry, Pharmacology +13

Biphasic Modulation of NOS Expression, Protein and Nitrite Products by Hydroxocobalamin Underlies Its Protective Effect in Endotoxemic Shock: Downstream Regulation of COX-2, IL-1<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi mathvariant="bold-italic">β</mml:mi></mml:mrow></mml:math>, TNF-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mrow><mml:mi mathvariant="bold-italic">α</mml:mi></mml:mrow></mml:math>, IL-6, and HMGB1 Expression

André Luiz Franco Sampaio, Jesmond Dalli, Vincenzo Brancaleone et al. · Mediators of Inflammation · 2013 · 36 citations · Full text

Veterinary Medicine, Immunology, Pharmacology +13

Cobalamin in inflammation III — glutathionylcobalamin and methylcobalamin/adenosylcobalamin coenzymes: the sword in the stone? How cobalamin may directly regulate the nitric oxide synthases

Carmen Wheatley · Journal of Nutritional & Environmental Medicine · 2007 · 12 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13