An Enzymatic Activity in the Yeast Sir2 Protein that Is Essential for Gene Silencing

Jason C. Tanny, Gustave J Dowd, Julie Huang, +2

Cell

ChromatinYeast Sir2 ProteinEnzymatic ActivityMedicineGenetics +8

Yng1 PHD Finger Binding to H3 Trimethylated at K4 Promotes NuA3 HAT Activity at K14 of H3 and Transcription at a Subset of Targeted ORFs

Sean D. Taverna, Serge Ilin, Richard S. Rogers, +11

Molecular Cell

ChromatinTranscriptional RegulationSignaling PathwayNatural SciencesGenetics +8

Steps in Assembly of Silent Chromatin in Yeast: Sir3-Independent Binding of a Sir2/Sir4 Complex to Silencers and Role for Sir2-Dependent Deacetylation

Georg J. Hoppe, Jason C. Tanny, Adam D. Rudner, +4

Molecular and Cellular Biology

Histone ModificationsGeneticsGenomic MechanismMolecular BiologyEpigenetics +19

Assembly of the SIR Complex and Its Regulation by O-Acetyl-ADP-Ribose, a Product of NAD-Dependent Histone Deacetylation

Gunn‐Guang Liou, Jason C. Tanny, Ryan G. Kruger, +2

Cell

ChromatinSir ComplexAldo-keto ReductaseBiochemistryChromatin Remodeling +9

Histone chaperone Asf1 is required for histone H3 lysine 56 acetylation, a modification associated with S phase in mitosis and meiosis

Judith Recht, Toshiaki Tsubota, Jason C. Tanny, +9

Proceedings of the National Academy of Sciences

Histone ModificationsHistone H3Histone BindingEpigenetic ChangeGenetics +21

Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product

Jason C. Tanny, Danesh Moazed

Proceedings of the National Academy of Sciences

Histone SubstrateChromatinNad BreakdownBiosynthesisAldo-keto Reductase +12

A Cdk9–PP1 switch regulates the elongation–termination transition of RNA polymerase II

Pabitra K. Parua, Gregory T. Booth, Miriam Sansó, +4

Nature

Transcriptional RegulationElongation–termination TransitionEngineeringCdk9–pp1 SwitchRna Polymerase Ii +8

Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation

Jason C. Tanny, Hediye Erdjument‐Bromage, Paul Tempst, +1

Genes & Development

Components of the ESCRT Pathway, <i>DFG16</i> , and <i>YGR122w</i> Are Required for Rim101 To Act as a Corepressor with Nrg1 at the Negative Regulatory Element of the <i>DIT1</i> Gene of <i>Saccharomyces cerevisiae</i>

Karen Rothfels, Jason C. Tanny, Enikő Molnár, +3

Molecular and Cellular Biology

Budding Yeast Silencing Complexes and Regulation of Sir2 Activity by Protein-Protein Interactions

Jason C. Tanny, Donald S. Kirkpatrick, Scott A. Gerber, +2

Molecular and Cellular Biology

Molecular RegulationGeneticsGenomic MechanismMolecular BiologySir2 Protein +18