Richard J. Spears

Evidence for a Boat Conformation at the Transition State of GH76 α‐1,6‐Mannanases—Key Enzymes in Bacterial and Fungal Mannoprotein Metabolism

Andrew J. Thompson, Gaetano Speciale, Javier Iglesias‐Fernández et al. · Angewandte Chemie International Edition · 2015 · 50 citations

Life Sciences, Biochemistry, Medicinal Chemistry +17

Disulfide Modified IgG1: An Investigation of Biophysical Profile and Clinically Relevant Fc Interactions

Calise Bahou, Elizabeth A. Love, Siobhán Leonard et al. · Bioconjugate Chemistry · 2019 · 46 citations · Full text

Pharmacy, Immunology, Pharmacology +17

Site-selective C–C modification of proteins at neutral pH using organocatalyst-mediated cross aldol ligations

Richard J. Spears, Robin Brabham, Darshita Budhadev et al. · Chemical Science · 2018 · 40 citations · Full text

Life Sciences, Biochemistry, Biotechnology +9

Palladium-unleashed proteins: gentle aldehyde decaging for site-selective protein modification

Robin Brabham, Richard J. Spears, Julia Walton et al. · Chemical Communications · 2018 · 25 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

A Plug-and-Play Platform for the Formation of Trifunctional Cysteine Bioconjugates that also Offers Control over Thiol Cleavability

Calise Bahou, Péter A. Szijj, Richard J. Spears et al. · Bioconjugate Chemistry · 2021 · 22 citations · Full text

Pharmacy, Biochemistry, Chemical Biology +9