Prime, Shock, and Kill: Priming CD4 T Cells from HIV Patients with a BCL-2 Antagonist before HIV Reactivation Reduces HIV Reservoir Size

Nathan W. Cummins, Amy M. Sainski, Haiming Dai, +10

Journal of Virology

Maintenance of the HIV Reservoir Is Antagonized by Selective BCL2 Inhibition

Nathan W. Cummins, Amy Sainski‐Nguyen, Sekar Natesampillai, +3

Journal of Virology

An advanced BLT-humanized mouse model for extended HIV-1 cure studies

Kerry J. Lavender, Craig S. Pace, Kathrin Sutter, +13

AIDS

Extensive virologic and immunologic characterization in an HIV-infected individual following allogeneic stem cell transplant and analytic cessation of antiretroviral therapy: A case study

Nathan W. Cummins, Stacey A. Rizza, Mark R. Litzow, +24

PLoS Medicine

Reactivating latent HIV with PKC agonists induces resistance to apoptosis and is associated with phosphorylation and activation of BCL2

Andrea French, Sekar Natesampillai, Ashton Krogman, +9

PLoS Pathogens

ApoptosisImmunologyCell DeathCd4 T Cell ResponsesImmunotherapy +16

The HIV-1-Specific Protein Casp8p41 Induces Death of Infected Cells through Bax/Bak

Amy M. Sainski, Sekar Natesampillai, Nathan W. Cummins, +5

Journal of Virology

Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation

Amy M. Sainski, Haiming Dai, Sekar Natesampillai, +12

The Journal of Cell Biology

Direct Bak ActivationApoptosisImmunologyT-regulatory CellCell Death +16

HIV Protease-Generated Casp8p41, When Bound and Inactivated by Bcl2, Is Degraded by the Proteasome

Sekar Natesampillai, Nathan W. Cummins, Zilin Nie, +9

Journal of Virology

Choice of antiretroviral therapy differentially impacts survival of HIV-infected CD4 T cells

Nathan W. Cummins, Amy M. Sainski, Sekar Natesampillai, +2

Molecular and Cellular Therapies

The BCL-2 Inhibitor Venetoclax Augments Immune Effector Function Mediated by Fas Ligand, TRAIL, and Perforin/Granzyme B, Resulting in Reduced Plasma Viremia and Decreased HIV Reservoir Size during Acute HIV Infection in a Humanized Mouse Model

Aswath P. Chandrasekar, Nathan W. Cummins, Sekar Natesampillai, +4

Journal of Virology