Axonal autophagosome maturation defect through failure of ATG9A sorting underpins pathology in AP-4 deficiency syndrome

Davor Ivankovic, James Drew, Flavie Lesept, +4

Autophagy

The adaptor proteins HAP1a and GRIP1 collaborate to activate the kinesin-1 isoform KIF5C

Alison E. Twelvetrees, Flavie Lesept, Erika L.F. Holzbaur, +1

Journal of Cell Science

Urokinase versus Alteplase for intraventricular hemorrhage fibrinolysis

Thomas Gaberel, Axel Montagne, Flavie Lesept, +7

Neuropharmacology

ThrombosisMedicineHemostasisFibrinolysisNeurology +4

Neuroendothelial NMDA receptors as therapeutic targets in experimental autoimmune encephalomyelitis

Richard Macrez, María Cristina Ortega, Isabelle Bardou, +12

Brain

Tissue-type plasminogen activator controls neuronal death by raising surface dynamics of extrasynaptic NMDA receptors

Flavie Lesept, Arnaud Chevilley, Julie Jézéquel, +14

Cell Death and Disease

Tissue Plasminogen Activator Expression Is Restricted to Subsets of Excitatory Pyramidal Glutamatergic Neurons

Morgane Louessard, Alexandre Lacroix, Magalie Martineau, +8

Molecular Neurobiology

NeurophysiologyNeurotransmitterNeurologyNeurotransmissionCentral Nervous System +7

Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo

Amandine Jullienne, Axel Montagne, Cyrille Orset, +6

Molecular Neurodegeneration

Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR

Thomas Bertrand, Flavie Lesept, Arnaud Chevilley, +7

Cell Death and Disease

Memantine Improves Safety of Thrombolysis for Stroke

Axel Montagne, Marie Hébert, Amandine Jullienne, +9

Stroke

SNX27-Mediated Recycling of Neuroligin-2 Regulates Inhibitory Signaling

Els F. Halff, Blanka R. Szulc, Flavie Lesept, +1

Cell Reports