Denis O′Shea

Copper(II) Complexes of Salicylic Acid Combining Superoxide Dismutase Mimetic Properties with DNA Binding and Cleaving Capabilities Display Promising Chemotherapeutic Potential with Fast Acting in Vitro Cytotoxicity against Cisplatin Sensitive and Resistant Cancer Cell Lines

Mark J. O’Connor, Andrew Kellett, Malachy McCann et al. · Journal of Medicinal Chemistry · 2012 · 166 citations

Engineering, Fast Acting, Molecular Biology +19

Synthesis, catalase, superoxide dismutase and antitumour activities of copper(II) carboxylate complexes incorporating benzimidazole, 1,10-phenanthroline and bipyridine ligands: X-ray crystal structures of [Cu(BZA)2(bipy)(H2O)], [Cu(SalH)2(BZDH)2] and [Cu(CH3COO)2(5,6-DMBZDH)2] (SalH2=salicylic acid; BZAH=benzoic acid; BZDH=benzimidazole and 5,6-DMBZDH=5,6-dimethylbenzimidazole)

Michael Devereux, Denis O′Shea, Mark J. O’Connor et al. · Polyhedron · 2007 · 142 citations

Inorganic Chemistry, Engineering, Coordination Complex +8

Insights Into the Mode of Action of the Anti‐<i>Candida</i> Activity of 1,10‐Phenanthroline and its Metal Chelates

Malachy McCann, Majella Geraghty, Michael Devereux et al. · Metal-Based Drugs · 2000 · 107 citations · Full text

Bis-phenanthroline copper(ii) phthalate complexes are potent in vitro antitumour agents with ‘self-activating’ metallo-nuclease and DNA binding properties

Andrew Kellett, Mark J. O’Connor, Malachy McCann et al. · Dalton Transactions · 2010 · 99 citations

Inorganic Chemistry, Phthalate Isomers, Engineering +13

Water-soluble bis(1,10-phenanthroline) octanedioate Cu2+ and Mn2+ complexes with unprecedented nano and picomolar in vitro cytotoxicity: promising leads for chemotherapeutic drug development

Andrew Kellett, Mark J. O’Connor, Malachy McCann et al. · MedChemComm · 2011 · 84 citations · Full text

Mn2+ Complexes, Chemoprevention Strategy, Molecular Biology +23