Concepedia

Author

Linda Gatchie

Indian Institute of Integrative Medicine

Also Known As

Linda Gatchie

12

Publications

326

Citations

11

H-Index

24

Concepts

All Affiliations

Indian Institute of Integrative MedicineDe Montfort UniversityAcademy of Scientific and Innovative ResearchBirla Institute of Technology, Mesra
LG

About

Linda Gatchie is an author at Indian Institute of Integrative Medicine specializing in medicine, pharmacology, and medicinal chemistry.

Top Concepts

#ConceptH-IndexPublicationsCitations

1

Medicine

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2

Natural Sciences

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65

3

Biochemistry

2

2

63

4

Engineering

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1

14

5

Biomolecular Engineering

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Linda Gatchie

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11

Publications

326

Citations

11

H-Index

YearCitations

Synthesis and biological evaluation of pyrrole-based chalcones as CYP1 enzyme inhibitors, for possible prevention of cancer and overcoming cisplatin resistance

Ibidapo S. Williams, Prashant Joshi, Linda Gatchie,

Bioorganic & Medicinal Chemistry Letters

2017

57

Quinazoline derivatives as selective CYP1B1 inhibitors

Mohd Usman Mohd Siddique, Glen J. P. McCann, Vinay R. Sonawane,

European Journal of Medicinal Chemistry

2017

54

Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines

Neill Horley, Kenneth J. M. Beresford, Tarun Chawla,

European Journal of Medicinal Chemistry

2017

51

Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme

Rajni Sharma, Linda Gatchie, Ibidapo S. Williams,

Bioorganic & Medicinal Chemistry Letters

2017

49

Khellinoflavanone, a Semisynthetic Derivative of Khellin, Overcomes Benzo[<i>a</i>]pyrene Toxicity in Human Normal and Cancer Cells That Express CYP1A1

Rajni Sharma, Ibidapo S. Williams, Linda Gatchie,

ACS Omega

2018

21

Identification of karanjin isolated from the Indian beech tree as a potent CYP1 enzyme inhibitor with cellular efficacy <i>via</i> screening of a natural product repository

Prashant Joshi, Vinay R. Sonawane, Ibidapo S. Williams,

MedChemComm

2018

20

Biotransformation, Using Recombinant CYP450-Expressing Baker’s Yeast Cells, Identifies a Novel CYP2D6.10<sup>A122V</sup> Variant Which Is a Superior Metabolizer of Codeine to Morphine Than the Wild-Type Enzyme

Ibidapo S. Williams, Linda Gatchie, Sandip B. Bharate,

ACS Omega

2018

16

CYP enzymes, expressed within live human suspension cells, are superior to widely-used microsomal enzymes in identifying potent CYP1A1/CYP1B1 inhibitors: Identification of quinazolinones as CYP1A1/CYP1B1 inhibitors that efficiently reverse B[a]P toxicity and cisplatin resistance

Vinay R. Sonawane, Mohd Usman Mohd Siddique, Linda Gatchie,

European Journal of Pharmaceutical Sciences

2019

16

(E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent

Neill Horley, Kenneth J. M. Beresford, Supriya Kaduskar,

Bioorganic & Medicinal Chemistry Letters

2017

15

Biotransformation of Chrysin to Baicalein: Selective C6-Hydroxylation of 5,7-Dihydroxyflavone Using Whole Yeast Cells Stably Expressing Human CYP1A1 Enzyme

Ibidapo S. Williams, Shifali Chib, Vijay K. Nuthakki,

Journal of Agricultural and Food Chemistry

2017

14

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