Tumour hypoxia causes DNA hypermethylation by reducing TET activity

Bernard Thienpont, Jessica Steinbacher, Hui Zhao, +16

Nature

ChromatinGenome InstabilityNatural SciencesEpigenetic ChangeEpigenomics +6

Antisense oligonucleotide–mediated MDM4 exon 6 skipping impairs tumor growth

Michael Dewaele, Tommaso Tabaglio, Karen Willekens, +24

Journal of Clinical Investigation

Tumor BiologyImpairs Tumor GrowthOncogenic AgentMedicineFull-length Mdm4 +10

PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models

Terrence F. Meehan, Nathalie Conte, Theodore C. Goldstein, +51

Cancer Research

Outcome of Colonic Surgery in Elderly Patients with Colon Cancer

Els Hermans, P.M. van Schaik, H. A. Prins, +3

Journal of Oncology

Surgical OncologyAgingElderly PatientsColorectal SurgeryCancer Management +15

Characterization of patient-derived tumor xenograft models of endometrial cancer for preclinical evaluation of targeted therapies

Jeroen Depreeuw, Els Hermans, Stefanie Schrauwen, +11

Gynecologic Oncology

Tumor BiologyPreclinical EvaluationMedicineGynecologyGynecology Oncology +9

Potential Targets' Analysis Reveals Dual PI3K/mTOR Pathway Inhibition as a Promising Therapeutic Strategy for Uterine Leiomyosarcomas—an ENITEC Group Initiative

Tine Cuppens, Daniela Annibali, An Coosemans, +28

Clinical Cancer Research

Spontaneous Post-Transplant Disorders in NOD.Cg- Prkdcscid Il2rgtm1Sug/JicTac (NOG) Mice Engrafted with Patient-Derived Metastatic Melanomas

Enrico Radaelli, Els Hermans, Lorna Omodho, +5

PLoS ONE

Cell TherapyImmunologyPathologyDermatologyImmunotherapy +22

Dual blockade of PI3K/AKT/mTOR (NVP-BEZ235) and Ras/Raf/MEK (AZD6244) pathways synergistically inhibit growth of primary endometrioid endometrial carcinoma cultures, whereas NVP-BEZ235 reduces tumor growth in the corresponding xenograft models

Stefanie Schrauwen, Jeroen Depreeuw, Lieve Coenegrachts, +3

Gynecologic Oncology

OncologyMedicineInhibit GrowthGynecologyCancer Growth +7

Establishment and characterization of uterine sarcoma and carcinosarcoma patient-derived xenograft models

Tine Cuppens, Jeroen Depreeuw, Daniela Annibali, +8

Gynecologic Oncology

Tumor BiologyTumoral PathologyPatient-derived Xenograft ModelsTumor HeterogeneityMedicine +7

Micro-metastases in stages I and II colon cancer are a predictor of the development of distant metastases and worse disease-free survival

P.M. van Schaik, Els Hermans, J.C. van der Linden, +3

European Journal of Surgical Oncology

Ii Colon CancerGastrointestinal OncologyMedicineColorectal CancerPathology +6