Gene silencing following siRNA delivery to skin via coated steel microneedles: In vitro and in vivo proof-of-concept

Rosalind Chong, Emilio González-González, M. Fernanda Lara, +6

Journal of Controlled Release

Regenerative MedicineTissue EngineeringGene TherapiesVivo Proof-of-conceptEngineering +9

Silencing of Reporter Gene Expression in Skin Using siRNAs and Expression of Plasmid DNA Delivered by a Soluble Protrusion Array Device (PAD)

Emilio González-González, Tycho J. Speaker, Robyn P. Hickerson, +5

Molecular Therapy

Tissue EngineeringEngineeringPad TipsMolecular BiologySkin Disorders +26

Inhibition of CD44 Gene Expression in Human Skin Models, Using Self-Delivery Short Interfering RNA Administered by Dissolvable Microneedle Arrays

M. Fernanda Lara, Emilio González-González, Tycho J. Speaker, +5

Human Gene Therapy

Dissolvable Microneedle ArraysImmunologySkin DisordersGene DeliveryDermatology +15

Gene expression profiling in pachyonychia congenita skin

Yu-An Cao, Robyn P. Hickerson, Brandon L. Seegmiller, +13

Journal of Dermatological Science

Skin DevelopmentCutaneous BiologyGeneticsGene ExpressionMedicine +1

Microencapsulation decreases the skin absorption of N,N-diethyl-m-toluamide (DEET)

Gerald B. Kasting, Varsha D. Bhatt, Tycho J. Speaker

Toxicology in Vitro

Skin AbsorptionTopical DrugMicro-encapsulationDermatology

A novel encapsulation of N,N-diethyl-3-methylbenzamide (DEET) favorably modifies skin absorption while maintaining effective evaporation rates

J.I. Karr, Tycho J. Speaker, Gerald B. Kasting

Journal of Controlled Release

Micro-encapsulationSkin PharmacologySkin AbsorptionDermatologyNovel Encapsulation +1

Gene Silencing in Skin After Deposition of Self-Delivery siRNA With a Motorized Microneedle Array Device

Robyn P. Hickerson, Winston C Wey, David L. Rimm, +7

Molecular Therapy — Nucleic Acids

Tissue EngineeringEngineeringPotent SirnasImmunologyGene Delivery +15

Visualization of plasmid delivery to keratinocytes in mouse and human epidermis

Emilio González-González, Yeu‐Chun Kim, Tycho J. Speaker, +11

Scientific Reports

Performance analysis of a 127-micron pixel large-area TFT/photodiode array with boosted fill factor

Richard L. Weisfield, William Yao, Tycho J. Speaker, +3

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

PhotonicsSensor Fill FactorEngineeringPerformance AnalysisMemory Effect +8