Nonsteroidal Selective Glucocorticoid Modulators:  the Effect of C-5 Alkyl Substitution on the Transcriptional Activation/Repression Profile of 2,5-Dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines

Steven W. Elmore, Michael J. Coghlan, David D. Anderson, +10

Journal of Medicinal Chemistry

C-5 Alkyl SubstitutionMedicinal ChemistryBioorganic ChemistryAllergyBiochemistry +13

Nonsteroidal Selective Glucocorticoid Modulators:  The Effect of C-10 Substitution on Receptor Selectivity and Functional Potency of 5-Allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines

Philip R. Kym, Michael E. Kort, Michael J. Coghlan, +17

Journal of Medicinal Chemistry

Functional PotencyMedicinal ChemistryC-10 SubstitutionBiochemistryG Protein-coupled Receptor +12

Synthesis and Characterization of Non-Steroidal Ligands for the Glucocorticoid Receptor:  Selective Quinoline Derivatives with Prednisolone-Equivalent Functional Activity

Michael J. Coghlan, Philip R. Kym, Steven W. Elmore, +10

Journal of Medicinal Chemistry

Medicinal ChemistryAllergyPrednisolone-equivalent Functional ActivityG Protein-coupled ReceptorMedicine +10

Randomized Comparison of 3 High-Level Disinfection and Sterilization Procedures for Duodenoscopes

Graham M. Snyder, Sharon B. Wright, Anne Smithey, +19

Gastroenterology

High-level DisinfectionSterilityPatient SafetySurgerySterilization Procedures +4

Hepatic Glucocorticoid Receptor Antagonism Is Sufficient to Reduce Elevated Hepatic Glucose Output and Improve Glucose Control in Animal Models of Type 2 Diabetes

Peer B. Jacobson, Thomas W von Geldern, Lars Öhman, +22

Journal of Pharmacology and Experimental Therapeutics

Identification and synthesis of a receptor binding site of human anaphylatoxin C5a

Megumi Kawai, David A. Quincy, Benjamin C. Lane, +3

Journal of Medicinal Chemistry

Smallest FragmentPeptide EngineeringImmunologyChemical BiologyInflammation +15

Structure-function studies in a series of carboxyl-terminal octapeptide analogs of anaphylatoxin C5a

Megumi Kawai, David A. Quincy, Benjamin C. Lane, +4

Journal of Medicinal Chemistry

Combinatorial ChemistryCarboxyl-terminal Octapeptide AnalogsHydrophobic Amino AcidsChemical BiologyStructure-function Studies +14

Structure‐activity profiles of macrolactam immunosuppressant FK‐506 analogues

Megumi Kawai, Benjamin C. Lane, Gin C. Hsieh, +3

FEBS Letters

Transplant RejectionSignal TransductionMedicineImmunosuppressive TherapyImmunology +10

Antidiabetic Activity of Passive Nonsteroidal Glucocorticoid Receptor Modulators

J. T. Link, Bryan K. Sorensen, Jyoti Patel, +17

Journal of Medicinal Chemistry

Glucocorticoid Receptor AntagonismMetabolic SyndromeGlucocorticoid Receptor ModulatorsBiochemistryMedicine +12

Adenosine Triphosphate Quantification Correlates Poorly with Microbial Contamination of Duodenoscopes

Lovisa Bjork Olafsdóttir, Sharon B. Wright, Anne Smithey, +6

Infection Control and Hospital Epidemiology