Scott M. Sheehan

Robust Central Reduction of Amyloid-β in Humans with an Orally Available, Non-Peptidic β-Secretase Inhibitor

Patrick C. May, Robert A. Dean, Stephen L. Lowe et al. · Journal of Neuroscience · 2011 · 369 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

The Potent BACE1 Inhibitor LY2886721 Elicits Robust Central Aβ Pharmacodynamic Responses in Mice, Dogs, and Humans

Patrick C. May, Brian A. Willis, Stephen L. Lowe et al. · Journal of Neuroscience · 2015 · 205 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

An Isomünchnone-Based Method for the Synthesis of Highly Substituted 2(1<i>H</i>)-Pyridones

Albert Padwa, Scott M. Sheehan, Christopher Straub · The Journal of Organic Chemistry · 1999 · 109 citations

Natural Sciences, Chemistry, Catalysis +14

Utilization of the Intramolecular Cycloaddition−Cationic π-Cyclization of an Isomünchnone Derivative for the Synthesis of (±)-Lycopodine

Albert Padwa, Michael A. Brodney, Joseph P. Marino et al. · The Journal of Organic Chemistry · 1997 · 105 citations

Natural Sciences, Chemistry, Medicinal Chemistry +13

Rhodium(II)-Catalyzed Equilibration of Push-Pull Carbonyl and Ammonium Ylides. A Computationally Based Understanding of the Reaction Pathway

Albert Padwa, James P. Snyder, Erin A. Curtis et al. · Journal of the American Chemical Society · 2000 · 89 citations

Natural Sciences, Chemistry, Catalysis +12