Tyrell R. Towle

Hidden Histidine Radical Rearrangements upon Electron Transfer to Gas-Phase Peptide Ions. Experimental Evidence and Theoretical Analysis

František Tureček, Jace W. Jones, Tyrell R. Towle et al. · Journal of the American Chemical Society · 2008 · 62 citations

Engineering, Radical Trapping Properties, Proton-coupled Electron Transfer +17

Bypassing Fluoroquinolone Resistance with Quinazolinediones: Studies of Drug–Gyrase–DNA Complexes Having Implications for Drug Design

Karl Drlica, Arkady Mustaev, Tyrell R. Towle et al. · ACS Chemical Biology · 2014 · 44 citations

Bioorganic Chemistry, Reverse Reaction, Molecular Biology +19

Design, synthesis, and evaluation of novel N-1 fluoroquinolone derivatives: Probing for binding contact with the active site tyrosine of gyrase

Tyrell R. Towle, Chaitanya A. Kulkarni, Lisa M. Oppegard et al. · Bioorganic & Medicinal Chemistry Letters · 2018 · 21 citations · Full text

Bioorganic Chemistry, Biochemistry, Natural Sciences +9

Chemical probes of a trisubstituted pyrrole to identify its protein target(s) in Plasmodium sporozoites

Tyrell R. Towle, Isabel Chang, Robert J. Kerns et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 10 citations · Full text

Molecular Recognition, Molecular Characterization, Bioorganic Chemistry +11

Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg2+ to the second metal binding site

Lisa M. Oppegard, Heidi A. Schwanz, Tyrell R. Towle et al. · Biochimica et Biophysica Acta (BBA) - General Subjects · 2015 · 10 citations · Full text

Biochemistry, Natural Sciences, Topoisomerase Iv +5