Innate-like functions of natural killer T cell subsets result from highly divergent gene programs

Isaac Engel, Grégory Seumois, Lukas Chávez, +6

Nature Immunology

Natural Killer CellsAdaptive Immune SystemT-regulatory CellImmunologyGene Expression +9

Acute loss of TET function results in aggressive myeloid cancer in mice

Jungeun An, Edahí González‐Avalos, Ashu Chawla, +7

Nature Communications

Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility

Grégory Seumois, Lukas Chávez, Matthias Lienhard, +10

Nature Immunology

AsthmaInflammatory Lung DiseaseImmune Cell DevelopmentT-regulatory CellImmunology +6

Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis

Jinsuk Kang, Matthias Lienhard, William A. Pastor, +10

Proceedings of the National Academy of Sciences

Predicting Extensively Drug-Resistant Mycobacterium tuberculosis Phenotypes with Genetic Mutations

Timothy C. Rodwell, Faramarz Valafar, James T. Douglas, +18

Journal of Clinical Microbiology

Genetic MutationsMycobacterium Tuberculosis IsolatesTuberculosis PreventionPathologyMolecular Diagnostic Methods +18

Novel<i>katG</i>mutations causing isoniazid resistance in clinical<i>M. tuberculosis</i>isolates

Jessica Torres, Lynthia Paul, Timothy C. Rodwell, +15

Emerging Microbes & Infections

Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging

Miriama Krutá, Mary Jean Sunshine, Bernadette A. Chua, +7

Cell stem cell

Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70

Meng Zhao, Mattias N. D. Svensson, Koen Venken, +8

Nature Communications

Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis

Bernadette A. Chua, Connor J. Lennan, Mary Jean Sunshine, +4

Cell stem cell

Transcriptomes and metabolism define mouse and human MAIT cell populations

Shilpi Chandra, Gabriel Ascui, Thomas Riffelmacher, +22

Science Immunology

Lymphocyte DevelopmentGeneticsImmune RegulationImmunologyGene Characterization +25