Carlos A. Rodríguez-Alarcón

The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets.

Carlos A. Rodríguez-Alarcón, Beth Lincoln, Christopher J. Rhodes · Journal of Biological Chemistry · 1993 · 150 citations · Full text

Glycobiology, Insulin Signaling, Gastrointestinal Peptide Hormone +18

Autocrine/paracrine role of insulin-related growth factors in neurogenesis: local expression and effects on cell proliferation and differentiation in retina.

Catalina Hernández‐Sánchez, Ana López‐Carranza, Carlos A. Rodríguez-Alarcón et al. · Proceedings of the National Academy of Sciences · 1995 · 103 citations · Full text

Insulin Receptor, Cell Growth, Cellular Physiology +19

The balance between proinsulin biosynthesis and insulin secretion: where can imbalance lead?

Yuji Uchizono, Carlos A. Rodríguez-Alarcón, Barton Wicksteed et al. · Diabetes Obesity and Metabolism · 2007 · 93 citations · Full text

Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus.

Carlos A. Rodríguez-Alarcón, Jack L. Leahy, G T Schuppin et al. · Journal of Clinical Investigation · 1995 · 92 citations · Full text

Proinsulin Conversion Enzymes, Secretory Demand, Insulin Signaling +18

Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level

Carlos A. Rodríguez-Alarcón, Barton Wicksteed, Christopher J. Rhodes · Diabetologia · 2006 · 77 citations · Full text

Glucose-stimulated Proinsulin Biosynthesis, Translational Level, Growth Hormone +10