A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites

Jakob Birnbaum, Sarah Scharf, Sabine Schmidt, +13

Science

Parasite ResistanceMalariaImmunologyMolecular BiologyHost Cell +16

A genetic system to study Plasmodium falciparum protein function

Jakob Birnbaum, Sven Flemming, Nick Reichard, +5

Nature Methods

MedicineGeneticsMalariaVector-parasite RelationshipGenetic System +6

Stable Translocation Intermediates Jam Global Protein Export in Plasmodium falciparum Parasites and Link the PTEX Component EXP2 with Translocation Activity

Paolo Mesén-Ramírez, Ferdinand Reinsch, Alexandra Blancke Soares, +4

PLoS Pathogens

Protein SecretionMalariaMolecular BiologyProtein TranslocationPlasmodium Falciparum Parasites +14

3-Aminooxy-1-Aminopropane and Derivatives Have an Antiproliferative Effect on Cultured <i>Plasmodium falciparum</i> by Decreasing Intracellular Polyamine Concentrations

Robin Das Gupta, Tanja Krause-Ihle, Bärbel Bergmann, +5

Antimicrobial Agents and Chemotherapy

Antiproliferative EffectBiochemistryAntiparasitic AgentMedicineMalaria +10

PfVPS45 Is Required for Host Cell Cytosol Uptake by Malaria Blood Stage Parasites

Ernst Jonscher, Sven Flemming, Marius Schmitt, +6

Cell Host & Microbe

Parasitic ProtozoaMalariaPathogenesisParasite ControlVirology +6

EXP1 is critical for nutrient uptake across the parasitophorous vacuole membrane of malaria parasites

Paolo Mesén-Ramírez, Bärbel Bergmann, Thuy Tuyen Tran, +6

PLoS Biology

Protein SecretionParasite Nutrient AcquisitionMalariaCellular PhysiologyMembrane Transport +16

Characterization and molecular cloning of a Cu/Zn superoxide dismutase from the human parasite Onchocerca volvulus

Kimberly J. Henkle, Eva Liebau, Sabine Müller, +2

Infection and Immunity

Antiparasitic AgentRedox BiologyCu/zn Superoxide DismutaseParasite GenomicsOxidative Stress +14

Chemical and genetic validation of thiamine utilization as an antimalarial drug target

Xie Wah Audrey Chan, Carsten Wrenger, Katharina Stahl, +4

Nature Communications

Antiparasitic AgentMalariaPharmacotherapyPlasmodium FalciparumDrug Resistance +14

Poisoning Pyridoxal 5-Phosphate-Dependent Enzymes: A New Strategy to Target the Malaria Parasite Plasmodium falciparum

Ingrid Müller, Fang Wu, Bärbel Bergmann, +4

PLoS ONE

Synthesis and antimalarial activity of chain substituted pivaloyloxymethyl ester analogues of Fosmidomycin and FR900098

Thomas Kurz, Katrin Schlüter, Uwe Kaula, +3

Bioorganic & Medicinal Chemistry

Medicinal ChemistryPivaloyloxymethyl Ester AnaloguesAntimalarial ActivityAntimicrobial CompoundPharmacology +3