Mechanisms and therapeutic implications of hypermutation in gliomas

Mehdi Touat, Yvonne Y. Li, Adam N. Boynton, +75

Nature

Neuro-oncologyMedicineTherapeutic ImplicationsHigh-grade GliomasCell Biology +3

DNA Damage-Induced Replication Fork Regression and Processing in <i>Escherichia coli</i>

Justin Courcelle, Janet R. Donaldson, Kin-Hoe Chow, +1

Science

Dna LesionsGenome InstabilityDna DamageNatural SciencesMolecular Biology +11

RecO Acts with RecF and RecR to Protect and Maintain Replication Forks Blocked by UV-induced DNA Damage in Escherichia coli

Kin-Hoe Chow, Justin Courcelle

Journal of Biological Chemistry

Nascent DNA processing by RecJ favors lesion repair over translesion synthesis at arrested replication forks in <i>Escherichia coli</i>

Charmain T. Courcelle, Kin-Hoe Chow, Andrew Casey, +1

Proceedings of the National Academy of Sciences

Dna LesionsBlocked Replication ForksGenome InstabilityDna DamageRecj Favors +13

miR-147b-mediated TCA cycle dysfunction and pseudohypoxia initiate drug tolerance to EGFR inhibitors in lung adenocarcinoma

Wen Cai Zhang, Julie Wells, Kin-Hoe Chow, +9

Nature Metabolism

Tumor BiologyMedicineLung AdenocarcinomaPathologyEgfr Inhibitors +7

VRK1 as a synthetic lethal target in VRK2 promoter–methylated cancers of the nervous system

Jonathan So, Nathaniel W. Mabe, Bernhard Englinger, +19

JCI Insight

Dna MethylationCell DeathCollateral LethalityCancer BiologyGlioma +14

Selective colonization ability of human fecal microbes in different mouse gut environments

Wei Zhou, Kin-Hoe Chow, Elizabeth Fleming, +1

The ISME Journal

Cancer-associated fibroblasts are the main contributors to epithelial-to-mesenchymal signatures in the tumor microenvironment

Péter M. Szabó, Amir Vajdi, Namit Kumar, +16

Scientific Reports

FGFR-inhibitor-mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance

Yihao Li, Xintao Qiu, Xiaoqing Wang, +20

Nature Cell Biology

Swi/snf ComplexesSignal TransductionSignaling PathwayFgfr-inhibitor-mediated DismissalReceptor Tyrosine Kinase +6

Functional drug susceptibility testing using single-cell mass predicts treatment outcome in patient-derived cancer neurosphere models

Max A. Stockslager, Seth Malinowski, Mehdi Touat, +8

Cell Reports