Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

Etienne Meylan, Joseph Curran, Kay Hofmann, +4

Nature

Adaptor ProteinRig-i Antiviral PathwayHepatitis C VirusViral HepatitisImmunology +6

Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children

Jennifer Loske, Jobst Röhmel, Soeren Lukassen, +20

Nature Biotechnology

Viral immune modulators perturb the human molecular network by common and unique strategies

Andreas Pichlmair, Kumaran Kandasamy, Gualtiero Alvisi, +20

Nature

Viral ReplicationSystems BiologyViral Immune ModulatorsHuman Molecular NetworkViral Persistence +9

SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB

Christopher J. Neufeldt, Berati Cerikan, Mirko Cortese, +19

Communications Biology

Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity

Cristhian Cadena, Sadeem Ahmad, Audrey Xavier, +8

Cell

Molecular ImmunologyE3 Ligase RipletInnate Immune SystemImmunologyImmunologic Mechanism +6

Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19

Saskia Trump, Soeren Lukassen, Markus S. Anker, +34

Nature Biotechnology

Activation of Type I and III Interferon Response by Mitochondrial and Peroxisomal MAVS and Inhibition by Hepatitis C Virus

Silke Bender, Antje Reuter, Florian Eberle, +3

PLoS Pathogens

Mavs Subcellular LocalizationHepatitis C VirusInnate Immune SystemImmunologyViral Pathogenesis +18

HBV Bypasses the Innate Immune Response and Does Not Protect HCV From Antiviral Activity of Interferon

Pascal Mutz, Philippe Metz, Florian A. Lempp, +17

Gastroenterology

Identification of type I and type II interferon-induced effectors controlling hepatitis C virus replication

Philippe Metz, Eva Dazert, Alessia Ruggieri, +10

Hepatology

Molecular Mechanism of Signal Perception and Integration by the Innate Immune Sensor Retinoic Acid-inducible Gene-I (RIG-I)

Marco Binder, Florian Eberle, Stefan Seitz, +7

Journal of Biological Chemistry

Viral ReplicationSignal PerceptionInnate Immune SystemImmunologyMolecular Biology +24