Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria

Geertrui Denecker, Dominique Vercammen, Margino Steemans, +8

Cell Death and Differentiation

InflammationMitophagySignal TransductionMitochondrial FunctionApoptosis +9

Tales of 1,008 small molecules: phenomic profiling through live-cell imaging in a panel of reporter cell lines

Michael J. Cox, Steffen Jaensch, Jelle Van de Waeter, +15

Scientific Reports

Evaluation of the Embryotoxic Potency of Compounds in a Newly Revised High Throughput Embryonic Stem Cell Test

Annelieke K. Peters, Margino Steemans, Erik Hansen, +3

Toxicological Sciences

Embryotoxic PotencyBiomedical EngineeringEmbryologyMedicinal ChemistryToxicology +14

Optimisation of the cell cultivation methods in the embryonic stem cell test results in an increased differentiation potential of the cells into strong beating myocard cells

Ann De Smedt, Margino Steemans, Marlies De Boeck, +5

Toxicology in Vitro

Embryo CultureRegenerative MedicineEmbryonic Stem CellDevelopmental BiologyMedicine +13

A Caspase-activated Factor (CAF) Induces Mitochondrial Membrane Depolarization and Cytochrome c Release by a Nonproteolytic Mechanism

Margino Steemans, Vera Goossens, Marc Van de Craen, +5

The Journal of Experimental Medicine

Flow cytometric analysis of micronucleated reticulocytes: Time- and dose-dependent response of known mutagens in mice, using multiple blood sampling

Marlies De Boeck, Bas‐jan van der Leede, Freddy Van Goethem, +4

Environmental and Molecular Mutagenesis

Flow Cytometric AnalysisImmunocytochemical TechniqueMicronucleated ReticulocytesMicroflow PlusImmunology +20

Protein Biomarkers for <i>in Vitro</i> Testing of Embryotoxicity

Karlfried Groebe, Martina Klemm-Manns, Gerhard Schwall, +13

Journal of Proteome Research

Stem Cell BiologyEmbryologyPre-clinical PharmacologyOxidative StressEmbryo Culture +22

Unexpected common mechanistic pathways for embryotoxicity of warfarin and lovastatin

Karlfried Groebe, Martina Klemm-Manns, Gerhard Schwall, +6

Reproductive Toxicology

ThrombosisDevelopmental BiologyMedicineStem Cell ToxicologyHematology +3

Evaluation of chronic drug-induced electrophysiological and cytotoxic effects using human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)

Cristina Altrocchi, Karel Van Ammel, Margino Steemans, +5

Frontiers in Pharmacology

A higher throughput method to the Embryonic Stem cell Test (EST), to detect embryotoxicity in early development

Annelieke K. Peters, Margino Steemans, Natalie Mesens, +5

Early DevelopmentGeneticsAdult Stem CellCell CultureEmbryology +17