Cynthia J. Sieben

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

Darren J. Baker, Bennett G. Childs, Matej Durik et al. · Nature · 2016 · 2.7K citations · Full text

Lifespan Extension, Developmental Biology, Aging +6

Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis

Reeja S. Maskey, Karen S. Flatten, Cynthia J. Sieben et al. · Nucleic Acids Research · 2017 · 121 citations · Full text

Autophagy activators suppress cystogenesis in an autosomal dominant polycystic kidney disease model

Ping Zhu, Cynthia J. Sieben, Xiaolei Xu et al. · Human Molecular Genetics · 2016 · 96 citations · Full text

Mitophagy, Autophagy Activation, Cyst Expansions +19

Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis

Marianna Trakala, Muskaan Aggarwal, Courtney Sniffen et al. · Genes & Development · 2021 · 63 citations · Full text

The genetic background significantly impacts the severity of kidney cystic disease in the Pkd1RC/RC mouse model of autosomal dominant polycystic kidney disease

Jennifer Arroyo, Diana Escobar-Zarate, Harrison H. Wells et al. · Kidney International · 2021 · 51 citations · Full text

Mendelian Disorder, Pkd1rc/rc Mouse Model, Medicine +13