Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity

Xiaohan Shi, Yunguang Li, Qiuyue Yuan, +17

Nature Communications

Metabolic classification suggests the GLUT1/ALDOB/G6PD axis as a therapeutic target in chemotherapy-resistant pancreatic cancer

Yunguang Li, Shijie Tang, Xiaohan Shi, +14

Cell Reports Medicine

Chemoprevention StrategyMetabolic RemodelingTumor BiologyPancreatic CancerOncology +15

Mutational Landscape and Evolutionary Pattern of Liver and Brain Metastasis in Lung Adenocarcinoma

Tao Jiang, Zhaoyuan Fang, Shijie Tang, +16

Journal of Thoracic Oncology

Somatic VariantMutational LandscapeTumor HeterogeneityLung AdenocarcinomaBrain Metastasis +9

Counteracting lineage-specific transcription factor network finely tunes lung adeno-to-squamous transdifferentiation through remodeling tumor immune microenvironment

Shijie Tang, Yun Xue, Zhen Qin, +20

National Science Review

EngineeringImmunologyPathologyTumor BiologyTumor Heterogeneity +16

Oxidative stress-triggered Wnt signaling perturbation characterizes the tipping point of lung adeno-to-squamous transdifferentiation

Zhaoyuan Fang, Xiangkun Han, Yueqing Chen, +14

Signal Transduction and Targeted Therapy

Molecular biomarkers, network biomarkers, and dynamic network biomarkers for diagnosis and prediction of rare diseases

Shijie Tang, Kai Yuan, Luonan Chen

Fundamental Research

EML4-ALK fusions drive lung adeno-to-squamous transition through JAK-STAT activation

Zhen Qin, Meiting Yue, Shijie Tang, +30

The Journal of Experimental Medicine

Integrated characterization of hepatobiliary tumor organoids provides a potential landscape of pharmacogenomic interactions

Yanjing Zhu, Shijie Tang, Qiuyue Yuan, +23

Cell Reports Medicine

Determination of tipping point in course of PM2.5 organic extracts-induced malignant transformation by dynamic network biomarkers

Chen Shen, Daochuan Li, Dianke Yu, +12

Journal of Hazardous Materials

Biomarker (Medicine)Chemoprevention StrategyOncogenic AgentMedicineBiomarker Target +6

TET2–STAT3–CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition

Yun Xue, Y. B. Chen, Sijia Sun, +20

The Journal of Experimental Medicine