Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection

Jin Wei, Mia Madel Alfajaro, Peter C. DeWeirdt, +28

Cell

Sars-cov-2 InfectionPathogenesisVirologyGene EditingGenome Editing +6

Antitumor activity of sorafenib in FLT3-driven leukemic cells

Daniel Auclair, David F. Miller, Victoria Yatsula, +15

Leukemia

Tumor BiologyAntitumor ActivityMedicineAnti-cancer AgentCancer Biology +2

Restriction of SARS-CoV-2 replication by targeting programmed −1 ribosomal frameshifting

Yu Sun, Laura Abriola, Rachel O. Niederer, +9

Proceedings of the National Academy of Sciences

Viral ReplicationViral Polymerase MechanismImmunologyMolecular BiologySars-cov-2 Replication +15

Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma

Ute I. Scholl, Laura Abriola, Chengbiao Zhang, +7

Journal of Clinical Investigation

Potassium Channel Kcnj5Aldo-keto ReductasePharmacotherapyCellular PhysiologyHyperpolarization (Biology) +16

Genome-wide CRISPR screen reveals host genes that regulate SARS-CoV-2 infection

Jin Wei, Mia Madel Alfajaro, Ruth E. Hanna, +24

Highlights Host GenesSars-cov-2 InfectionPathogenesisImmunologyViral Pathogenesis +13

Identification of Inhibitors of Inositol 5-Phosphatases through Multiple Screening Strategies

Michelle Pirruccello, Ramiro Nández, Olof Idevall‐Hagren, +6

ACS Chemical Biology

Proteinlipid InteractionDrug TargetLipid MovementChemical BiologyMedicinal Chemistry +15

Increased numbers of nucleoli in a genome-wide RNAi screen reveal proteins that link the cell cycle to RNA polymerase I transcription

Lisa M. Ogawa, Amber F. Buhagiar, Laura Abriola, +3

Molecular Biology of the Cell

GeneticsMolecular BiologyMcf10a CellsCell CycleGene Transcription +20

A high-throughput assay for directly monitoring nucleolar rRNA biogenesis

Carson J. Bryant, Mason A. McCool, Laura Abriola, +2

Open Biology

Phosphorylated WNK kinase networks in recoded bacteria recapitulate physiological function

Paula Schiapparelli, Natasha L. Pirman, Kyle Mohler, +14

Cell Reports

Signal TransductionMolecular PhysiologyCell SignalingWnk Kinase NetworksCellular Regulatory Mechanism +7

DNA Polymerase Beta Germline Variant Confers Cellular Response to Cisplatin Therapy

Antonia A. Nemec, Laura Abriola, Jane S. Merkel, +5

Molecular Cancer Research