Efficient Transplantation via Antibody-Based Clearance of Hematopoietic Stem Cell Niches

Agnieszka Czechowicz, Daniel Kraft, Irving L. Weissman, +1

Science

Cell TherapyImmunologyImmunotherapyStem Cell MobilizationStem Cell Transplantation +15

Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment

G‐One Ahn, Diane Tseng, Cho-Hwa Liao, +3

Proceedings of the National Academy of Sciences

Cd11b Monoclonal AntibodiesImmunologyMyeloid Cell RecruitmentImmunotherapyCancer Biology +16

Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin

Rahul Palchaudhuri, Borja Sáez, Jonathan Hoggatt, +10

Nature Biotechnology

Cell TherapyTransplantationMarrow TransplantationStem Cell MobilizationStem Cell Transplantation +9

Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation

Agnieszka Czechowicz, Rahul Palchaudhuri, Amelia Scheck, +13

Nature Communications

Hematopoietic Stem Cell Quiescence Attenuates DNA Damage Response and Permits DNA Damage Accumulation During Aging

Derrick J. Rossi, Jun Seita, Agnieszka Czechowicz, +3

Cell Cycle

ChromatinGenome InstabilityStem Cell QuiescenceDna DamageAging +13

Niche recycling through division-independent egress of hematopoietic stem cells

Deepta Bhattacharya, Agnieszka Czechowicz, A. G. Lisa Ooi, +3

The Journal of Experimental Medicine

Clonal-level lineage commitment pathways of hematopoietic stem cells in vivo

Rong Lu, Agnieszka Czechowicz, Jun Seita, +2

Proceedings of the National Academy of Sciences

Anti-CD117 antibody depletes normal and myelodysplastic syndrome human hematopoietic stem cells in xenografted mice

Wendy W. Pang, Agnieszka Czechowicz, Aaron C. Logan, +5

Blood

Anti-KIT monoclonal antibody inhibits imatinib-resistant gastrointestinal stromal tumor growth

Badreddin Edris, Stephen B. Willingham, Kipp Weiskopf, +10

Proceedings of the National Academy of Sciences

In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice

S. Christopher Derderian, Priya Togarrati, Charmin King, +5

Blood