Rhenium Carbonyl Complexes of .beta.-Estradiol Derivatives with High Affinity for the Estradiol Receptor: An Approach to Selective Organometallic Radiopharmaceuticals

Siden Top, Hassane El Hafa, Anne Vessières, +7

Journal of the American Chemical Society

A genetic algorithm for the automated generation of small organic molecules: Drug design using an evolutionary algorithm

Dominique Douguet, E. Thoreau, Gérard Grassy

Journal of Computer-Aided Molecular Design

Structural symmetry of the extracellular domain of the Cytokine/Growth hormone/Prolactin receptor family and Interferon receptors revealed by Hydrophobic Cluster Analysis

E. Thoreau, Barbara B. Petridou, Paul A. Kelly, +2

FEBS Letters

Extracellular DomainImmunologyMolecular BiologyAntigen ProcessingCytoskeleton +22

Comparison of three algorithms for the assignment of secondary structure in proteins: the advantages of a consensus assignment

N. Colloc’h, E. Thoreau, Bernard Henrissat, +1

Protein Engineering Design and Selection

Structural BioinformaticsBiomolecular Structure PredictionSecondary StructureMolecular BiologyAccurate Assignments +14

Nonclinical and human pharmacology of the potent and selective topical retinoic acid receptor-γ agonist trifarotene

Jacques Aubert, David Piwnica, Béatrice Bertino, +17

British Journal of Dermatology

Discovery of phenoxyindazoles and phenylthioindazoles as RORγ inverse agonists

Gilles Ouvry, Claire Bouix‐Peter, Fabrice Ciesielski, +20

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyDrug TargetMedicinePharmacological AgentPharmacotherapy +4

Structure-based design of Trifarotene (CD5789), a potent and selective RARγ agonist for the treatment of acne

E. Thoreau, Jean-Marie Arlabosse, Claire Bouix‐Peter, +14

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryMedicineNatural SciencesStructure-based Design +5

Squaramides as novel class I and IIB histone deacetylase inhibitors for topical treatment of cutaneous t-cell lymphoma

Jean‐François Fournier, Yushma Bhurruth-Alcor, Branislav Musicki, +24

Bioorganic & Medicinal Chemistry Letters

Cutaneous T-cell LymphomaMedicinal ChemistryLymphoid NeoplasiaMedicinePharmacology +9

Rational Drug Design of Topically Administered Caspase 1 Inhibitors for the Treatment of Inflammatory Acne

Jean‐François Fournier, Laurence Clary, Sandrine Chambon, +26

Journal of Medicinal Chemistry

Pharmaceutical ScienceImmunologyPeptide SciencePharmacotherapyImmunotherapeutics +16

Sulfoximines as potent RORγ inverse agonists

Gilles Ouvry, Franck Bihl, Claire Bouix‐Peter, +24

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryMedicineMechanism Of ActionPharmacological Agent +4