Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases

Haitao Yang, Weiqing Xie, Xiaoyu Xue, +16

PLoS Biology

Synthetic VirologyMolecular BiologyAntiviral DrugViral Structural ProteinVirus Structure +14

Structures of Two Coronavirus Main Proteases: Implications for Substrate Binding and Antiviral Drug Design

Xiaoyu Xue, Hongwei D. Yu, Haitao Yang, +9

Journal of Virology

Production of Authentic SARS-CoV Mpro with Enhanced Activity: Application as a Novel Tag-cleavage Endopeptidase for Protein Overproduction

Xiaoyu Xue, Haitao Yang, Qi Zhao, +6

Journal of Molecular Biology

Protein ExpressionBiochemistryEnhanced ActivityNatural SciencesNovel Tag-cleavage Endopeptidase +6

Chromatin‐bound <scp>cGAS</scp> is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death

Hui Jiang, Xiaoyu Xue, Swarupa Panda, +6

The EMBO Journal

Small molecules combined with collagen hydrogel direct neurogenesis and migration of neural stem cells after spinal cord injury

Yaming Yang, Yongheng Fan, Haipeng Zhang, +10

Biomaterials

Tissue EngineeringEngineeringBiofabricationBiomedical EngineeringRegenerative Medicine +15

UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide

Carmen Pérez‐Calero, Aleix Bayona‐Feliú, Xiaoyu Xue, +5

Genes & Development

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions

Marcel Hohl, Youngho Kwon, Sandra Muñoz-Galván, +5

Nature Structural & Molecular Biology

Rad50 Coiled-coil DomainMagnetic ResonanceMolecular BiologyStructural BiologyMedicine +1

A functional scaffold to promote the migration and neuronal differentiation of neural stem/progenitor cells for spinal cord injury repair

Weiyuan Liu, Xu Bai, Weiwei Xue, +11

Biomaterials

Regenerative MedicineNeuroregenerationSpinal Cord InjuryDevelopmental BiologyMedicine +11

Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates

Jacob N. Bonner, Koyi Choi, Xiaoyu Xue, +10

Cell Reports

Enhancement of BLM-DNA2-Mediated Long-Range DNA End Resection by CtIP

James M. Daley, Judit Jiménez-Sáinz, Weibin Wang, +5

Cell Reports

ChromatinGenome InstabilityEnd ResectionChromatin RemodelingNatural Sciences +11