Regulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: role of coenzyme A, acetyl-coenzyme A and reduced and oxidized nicotinamide-adenine dinucleotide

A L Kerbey, P J Randle, RA Cooper, +3

Biochemical Journal

Lipid PeroxidationMetabolic RemodelingRedox BiologyOxidative StressMetabolic Syndrome +17

Regulation of mammalian pyruvate dehydrogenase

Richard M. Denton, Philip J. Randle, B J Bridges, +6

Molecular and Cellular Biochemistry

Energy MetabolismMammalian Pyruvate DehydrogenaseBiochemistryPhysiologyMetabolic Control +4

Diabetes and the control of pyruvate dehydrogenase in rat heart mitochondria by concentration ratios of adenosine triphosphate/adenosine diphosphate, of reduced/oxidized nicotinamide-adenine dinucleotide and of acetyl-coenzyme A/coenzyme A.

A L Kerbey, P M Radcliffe, P J Randle

Biochemical Journal

Concentration RatiosOxidative StressMetabolic SyndromeRat Heart MitochondriaHealth Sciences +14

Pyruvate dehydrogenase kinase/activator in rat heart mitochondria, Assay, effect of starvation, and effect of protein-synthesis inhibitors of starvation

A L Kerbey, P J Randle

Biochemical Journal

Protein-synthesis InhibitorsMetabolic RemodelingCellular PhysiologyOxidative StressRat Heart Mitochondria +15

Phosphorylation of additional sites on pyruvate dehydrogenase inhibits its re-activation by pyruvate dehydrogenase phosphate phosphatase

P H Sugden, Nancy J. Hutson, A L Kerbey, +1

Biochemical Journal

Energy MetabolismSignal TransductionMolecular PhysiologyBiochemistryCellular Enzymology +12

Amino acid sequences around the sites of phosphorylation in the pig heart pyruvate dehydrogenase complex

P H Sugden, A L Kerbey, P J Randle, +2

Biochemical Journal

Excess AtpMetabolic PathwaysSignal TransductionEnergy MetabolismBiochemistry +13

Kinase activator protein mediates longer-term effects of starvation on activity of pyruvate dehydrogenase kinase in rat liver mitochondria

Gareth Denyer, A L Kerbey, P J Randle

Biochemical Journal

Rat Liver MitochondriaMetabolic RemodelingOxidative StressPdh Kinase ActivityKinase Activator Protein +16

Regulation of pyruvate oxidation and the conservation of glucose.

P J Randle, P H Sugden, A L Kerbey, +2

PubMed

Glucose ConservationMetabolic RemodelingNutrient MetabolismInsulin SignalingOxidative Stress +18

Regulation of kinase reactions in pig heart pyruvate dehydrogenase complex

A L Kerbey, P M Radcliffe, P J Randle, +1

Biochemical Journal

Metabolic RemodelingCellular PhysiologyOxidative StressBioenergeticsApparent Km +19

Cyclic AMP and free fatty acids in the longer-term regulation of pyruvate dehydrogenase kinase in rat soleus muscle

Pamela B. Stace, Hasmukh R. Fatania, Amanda Jackson, +2

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Rat Soleus MuscleEnergy MetabolismMolecular PhysiologyMuscle FunctionBiochemistry +10