Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1

Bridget S. Gosis, Shogo Wada, Chelsea Thorsheim, +15

Science

ImmunologyPathologyPharmacotherapyRapamycin Complex 1Fatty Liver Disease +21

Comprehensive quantification of metabolic flux during acute cold stress in mice

Marc R. Bornstein, Michael D. Neinast, Xianfeng Zeng, +7

Cell Metabolism

InflammationAnimal PhysiologyEnergy MetabolismAcute Cold StressHyperthermia +10

Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms

Baobing Zhao, Yang Mei, Lan Cao, +14

Journal of Clinical Investigation

InflammationHematological MalignancyJak2v617f-induced MpnsJak2/stat5 PathwayImmunology +13

Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance

Megan C. Blair, Michael D. Neinast, Cholsoon Jang, +12

Nature Metabolism

Insulin ResistanceMetabolic SyndromeMuscle FunctionSkeletal MuscleMedicine +7

Folliculin promotes substrate-selective mTORC1 activity by activating RagC to recruit TFE3

Kristina Li, Shogo Wada, Bridget S. Gosis, +3

PLoS Biology

Molecular RegulationImmunologyMolecular BiologyMtor PathwayCellular Physiology +14

Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis

Liang Zhao, Chelsea Thorsheim, Aae Suzuki, +8

Nature Communications

Control of ribosomal RNA synthesis by hematopoietic transcription factors

Charles Antony, Subin S. George, Justin Blum, +13

Molecular Cell

ChromatinGeneticsRibosomal Rna SynthesisGene TranscriptionGene Expression +2

RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival

Daniel DeHelian, Shuchi Gupta, Jie Wu, +9

Blood

Phosphatidylinositol transfer proteins regulate megakaryocyte TGF-β1 secretion and hematopoiesis in mice

Maegan L. Capitano, Liang Zhao, Scott Cooper, +7

Blood

Quantification of nutrient fluxes during acute exercise in mice

Jessie Axsom, Tara TeSlaa, Won Dong Lee, +10

Cell Metabolism