Ilona J. de Graaf

Targeting pancreatic cancer by TAK-981: a SUMOylation inhibitor that activates the immune system and blocks cancer cell cycle progression in a preclinical model

Sumit Kumar, Mark J.A. Schoonderwoerd, Jessie S. Kroonen et al. · Gut · 2022 · 120 citations · Full text

Loss of nuclear UBE3A activity is the predominant cause of Angelman syndrome in individuals carrying UBE3A missense mutations

Stijn N. V. Bossuyt, A. Mattijs Punt, Ilona J. de Graaf et al. · Human Molecular Genetics · 2021 · 31 citations · Full text

SENP6 regulates localization and nuclear condensation of DNA damage response proteins by group deSUMOylation

Laura A. Claessens, Matty Verlaan–de Vries, Ilona J. de Graaf et al. · Nature Communications · 2023 · 29 citations · Full text

Inhibition of SUMOylation enhances DNA hypomethylating drug efficacy to reduce outgrowth of hematopoietic malignancies

Jessie S. Kroonen, Ilona J. de Graaf, Sumit Kumar et al. · Leukemia · 2023 · 20 citations · Full text

Mono-ubiquitination of Rabphilin 3A by UBE3A serves a non-degradative function

Rossella Avagliano Trezza, A. Mattijs Punt, Edwin Mientjes et al. · Scientific Reports · 2021 · 14 citations · Full text