Ryuichi Kambayashi

Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts

Aneesh Karkhanis, Gopalakrishnan Venkatesan, Ryuichi Kambayashi et al. · Acta Pharmaceutica Sinica B · 2022 · 21 citations · Full text

In vivo analysis of torsadogenic potential of an antipsychotic drug paliperidone using the acute atrioventricular block rabbit as a proarrhythmia model

Mihoko Hagiwara, Ryuichi Kambayashi, Megumi Aimoto et al. · Journal of Pharmacological Sciences · 2016 · 13 citations · Full text

Cardiovascular Pharmacology, Psychopharmacology, Electrophysiological Parameters +16

Dasatinib can Impair Left Ventricular Mechanical Function But May Lack Proarrhythmic Effect: A Proposal of Non-clinical Guidance for Predicting Clinical Cardiovascular Adverse Events of Tyrosine Kinase Inhibitors

Hiroko Izumi‐Nakaseko, Masachika Fujiyoshi, Mihoko Hagiwara-Nagasawa et al. · Cardiovascular Toxicology · 2019 · 13 citations

Cardiomyopathy, Non-clinical Guidance, Cardiovascular Disease +8

The anaesthetized rabbit with acute atrioventricular block provides a new model for detecting drug‐induced Torsade de Pointes

Mihoko Hagiwara, Seiji Shibuta, Kazuhiro Takada et al. · British Journal of Pharmacology · 2017 · 12 citations · Full text

Analysis of electropharmacological and proarrhythmic effects of donepezil using the halothane-anesthetized intact dogs and the conscious chronic atrioventricular block ones

Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Ai Goto et al. · Naunyn-Schmiedeberg s Archives of Pharmacology · 2020 · 12 citations

Cardiac Anaesthesia, Anaesthetic Agent, Cardiovascular Disease +10