High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire

Brandon J. DeKosky, Gregory C. Ippolito, Ryan Deschner, +12

Nature Biotechnology

Functional GenomicsAutoimmune DiseaseMedicineGeneticsNext-generation Sequencing +12

Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells

May Daher, Rafet Başar, Elif Gokdemir, +52

Blood

CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression

Kristen Fousek, Junji Watanabe, Sujith K. Joseph, +22

Leukemia

Engineering of protease variants exhibiting high catalytic activity and exquisite substrate selectivity

Navin Varadarajan, Jongsik Gam, Mark Olsen, +2

Proceedings of the National Academy of Sciences

A high-throughput single-cell analysis of human CD8+ T cell functions reveals discordance for cytokine secretion and cytolysis

Navin Varadarajan, Boris Jülg, Yvonne J. Yamanaka, +10

Journal of Clinical Investigation

Adaptive Immune SystemImmunodeficienciesT-regulatory CellImmunologyImmune Regulation +26

KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape

Ye Li, Rafet Başar, Guohui Wang, +29

Nature Medicine

Natural Killer CellsImmunologyTumor EscapeCell DeathImmune Checkpoint Inhibitor +8

Interleukin-15-armoured GPC3 CAR T cells for patients with solid cancers

David Steffin, Nisha Ghatwai, Antonino Montalbano, +29

Nature

Cancer ImmunosurveillanceSolid CancersMedicineImmunologyImmune Checkpoint Inhibitor +3

IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions

Chang‐Han Lee, Gabrielle Romain, Wupeng Yan, +22

Nature Immunology

Molecular ImmunologyComplement SystemSignal TransductionImmune Effector FunctionsEffector Fcγ Receptors +12

A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens

Christopher L. Yankaskas, Keyata N. Thompson, Colin D. Paul, +10

Nature Biomedical Engineering

Breast OncologyOncologyEngineeringCancer DetectionMedicine +9

Rapid, efficient functional characterization and recovery of HIV-specific human CD8 ⁺ T cells using microengraving

Navin Varadarajan, Douglas S. Kwon, Kenneth Law, +5

Proceedings of the National Academy of Sciences