Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization

Damien Maurel, Laëtitia Comps‐Agrar, Carsten Brock, +9

Nature Methods

Protein AssemblyProtein FoldingNatural SciencesMolecular BiologyTime-resolved Fret +5

Hypothalamic Tanycytes Are an ERK-Gated Conduit for Leptin into the Brain

Églantine Balland, Julie Dam, Fanny Langlet, +11

Cell Metabolism

HypothalamusNeuroanatomyNeurophysiologyPhysiologyNeuroendocrine Mechanism +11

Time-resolved FRET between GPCR ligands reveals oligomers in native tissues

Laura Albizu, Martin Cottet, Michaela Králíková, +16

Nature Chemical Biology

Signal TransductionMolecular PhysiologyG Protein-coupled ReceptorNatural SciencesReceptor (Biochemistry) +9

A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors

Etienne Doumazane, Pauline Scholler, Jurriaan M. Zwier, +3

The FASEB Journal

Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons

Marie Schaeffer, Fanny Langlet, Chrystel Lafont, +15

Proceedings of the National Academy of Sciences

OptogeneticsCellular PhysiologyGastrointestinal Peptide HormonePeripheral SignalsNeuroendocrine Mechanism +14

Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy

Rita Rahmeh, Marjorie Damian, Martin Cottet, +13

Proceedings of the National Academy of Sciences

Molecular BiologyCell SignalingG ProteinMolecular PhysiologyBiochemistry +15

A Fluorescent Ligand-Binding Alternative Using Tag-lite® Technology

Jurriaan M. Zwier, Thomas Roux, Martin Cottet, +13

SLAS DISCOVERY

Drug TargetEngineeringQuantitative PharmacologyPeptide ScienceMolecular Pharmacology +18

Leptin brain entry via a tanycytic LepR–EGFR shuttle controls lipid metabolism and pancreas function

Manon Duquenne, Cintia Folgueira, Cyril Bourouh, +24

Nature Metabolism

Metabolic SyndromePancreas FunctionSignal TransductionMolecular PhysiologyHealth Sciences +9

A peptide competing with VEGF165 binding on neuropilin-1 mediates targeting of a chlorin-type photosensitizer and potentiates its photodynamic activity in human endothelial cells

Loraine Tirand, Céline Frochot, Régis Vanderesse, +6

Journal of Controlled Release

OptogeneticsChlorin-type PhotosensitizerPhotoreceptor CellAngiogenesisSignal Transduction +11

d-myo-Inositol 1-phosphate as a surrogate of d-myo-inositol 1,4,5-tris phosphate to monitor G protein-coupled receptor activation

Eric Trinquet, Michel Fink, Hervé Bazin, +16

Analytical Biochemistry

Signal TransductionMolecular PhysiologyBiochemistryG Protein-coupled ReceptorMedicine +7