Nanoparticle-Assisted Targeted Delivery of Eye-Specific Genes to Eyes Significantly Improves the Vision of Blind Mice In Vivo

Ammaji Rajala, Yuhong Wang, Ye Zhu, +4

Nano Letters

EngineeringNanoparticle-assisted Targeted DeliveryEye TissueGene DeliveryBiomedical Engineering +14

Loss of Neuroprotective Survival Signal in Mice Lacking Insulin Receptor Gene in Rod Photoreceptor Cells

Ammaji Rajala, Masaki Tanito, Yun Le, +2

Journal of Biological Chemistry

The Warburg Effect Mediator Pyruvate Kinase M2 Expression and Regulation in the Retina

Raju V. S. Rajala, Ammaji Rajala, Christopher Kooker, +2

Scientific Reports

Pyruvate kinase M2 regulates photoreceptor structure, function, and viability

Ammaji Rajala, Yuhong Wang, Richard S. Brush, +7

Cell Death and Disease

Diabetes Reduces Autophosphorylation of Retinal Insulin Receptor and Increases Protein-Tyrosine Phosphatase-1B Activity

Raju V. S. Rajala, Brandt Wiskur, Masaki Tanito, +2

Investigative Ophthalmology & Visual Science

Cell-Specific Promoters Enable Lipid-Based Nanoparticles to Deliver Genes to Specific Cells of the Retina <i>In Vivo</i>

Yuhong Wang, Ammaji Rajala, Binrui Cao, +4

Theranostics

Specific CellsNanomedicineCell-based Drug DeliveryPhotoreceptor CellRetina +11

Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotection

Ammaji Rajala, Vivek Gupta, Robert E. Anderson, +1

Mitochondrion

Mitochondrial HexokinaseGanglion CellSignal TransductionMolecular PhysiologyMitochondrial Function +12

Insulin Receptor Signaling in Cones

Ammaji Rajala, Radhika Dighe, Martin‐Paul Agbaga, +2

Journal of Biological Chemistry

Ocular DiseaseCell DeathInsulin SignalingRetinaSystemic Administration +15

G-protein-coupled Receptor Rhodopsin Regulates the Phosphorylation of Retinal Insulin Receptor

Ammaji Rajala, Robert E. Anderson, Jian‐xing Ma, +3

Journal of Biological Chemistry

Insulin ReceptorCone TransductionInsulin SignalingPhototropinMolecular Pharmacology +19

Activation and membrane binding of retinal protein kinase Bα/Akt1 is regulated through light‐dependent generation of phosphoinositides

Guiyuan Li, Ammaji Rajala, Allan F. Wiechmann, +2

Journal of Neurochemistry