A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies

Rogier W. Sanders, Ronald Derking, Albert Cupo, +16

PLoS Pathogens

Bg505 Sosip.664 Gp140Trimeric MimicsHuman RetrovirusImmunologyMultiple Epitopes +13

Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes

Steven W. de Taeye, Gabriel Ozorowski, Alba Torrents de la Peña, +28

Cell

Human RetrovirusImmunologyAntiviral TherapyAntiviral ResponseVirology +5

A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure

Jeong Hyun Lee, Raiees Andrabi, Ching-Yao Su, +15

Immunity

A Native-Like SOSIP.664 Trimer Based on an HIV-1 Subtype B <i>env</i> Gene

Pavel Pugach, Gabriel Ozorowski, Albert Cupo, +16

Journal of Virology

Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle

Philip J. M. Brouwer, Aleksandar Antanasijevic, Zachary T. Berndsen, +28

Nature Communications

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo

Max Medina-Ramírez, Fernando Garcés, Amelia Escolano, +30

The Journal of Experimental Medicine

Virus StructureCrystal StructureHuman RetrovirusImmunologyGl-targeting Trimer +13

Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens

George Ueda, Aleksandar Antanasijevic, Jorge A. Fallas, +22

eLife

Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation

Rajesh P. Ringe, Rogier W. Sanders, Anila Yasmeen, +11

Proceedings of the National Academy of Sciences

Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization

Alba Torrents de la Peña, Jean‐Philippe Julien, Steven W. de Taeye, +26

Cell Reports

Human RetrovirusImmunologyAntiviral ResponseVirologyChronic Viral Infection +4

An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability

Marit J. van Gils, Tom L.G.M. van den Kerkhof, Gabriel Ozorowski, +24

Nature Microbiology

Hiv-1 AntibodyHuman RetrovirusFusion PeptideImmunologyAntiviral Response +7