Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells.

Glenn C. Rice, Cheryl Sew Hoy, Robert Schimke

Proceedings of the National Academy of Sciences

Gene AmplificationGeneticsPathologyRedox BiologyTumor Biology +18

Overreplication and recombination of DNA in higher eukaryotes: potential consequences and biological implications.

Robert Schimke, Steven W. Sherwood, Anna B. Hill, +1

Proceedings of the National Academy of Sciences

Biological ImplicationsDna DamageHigher EukaryotesGeneticsGenomic Mechanism +19

Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica.

Jeffrey A. Coderre, Stephen M. Beverley, Robert Schimke, +1

Proceedings of the National Academy of Sciences

Gene AmplificationBiosynthesisEngineeringCellular EnzymologyBiochemistry +11

Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells.

Bruce J. Dolnick, Ronald Berenson, Joseph R. Bertino, +3

The Journal of Cell Biology

Gene AmplificationL5178y CellsCytogeneticsGeneticsGenomic Mechanism +21

Cytotoxic effects of cell cycle phase specific agents: result of cell cycle perturbation.

Andrew L. Kung, A. Zetterberg, Steven W. Sherwood, +1

PubMed

ApoptosisCell DeathCellular PharmacologyCell CycleTumor Biology +15

Opposite-strand RNAs from the 5' flanking region of the mouse dihydrofolate reductase gene.

Peggy Farnham, John Abrams, Robert Schimke

Proceedings of the National Academy of Sciences

Reductase MrnasGeneticsMolecular BiologyMolecular GeneticsGene Transcription +17

Protein degradation in human fibroblasts (WI-38). Effects of aging, viral transformation, and amino acid analogs.

Matthews O. Bradley, Leonard Hayflick, Robert Schimke

Journal of Biological Chemistry

Viral ReplicationImmunologyCell DeathDegradation RatesBiogerontology +17

S phase-specific synthesis of dihydrofolate reductase in Chinese hamster ovary cells.

Brian D. Mariani, Doris L. Slate, Robert Schimke

Proceedings of the National Academy of Sciences

Dhfr ActivityAldo-keto ReductaseMolecular BiologyCell CycleRedox Biology +17

Amplification of Dihydrofolate Reductase Genes in Methotrexate-resistant Cultured Mouse Cells

Robert Schimke, F W Alt, Rodney E. Kellems, +2

Cold Spring Harbor Symposia on Quantitative Biology

Reductive StressCellular EnzymologyBiochemistryDihydrofolate Reductase GenesMedicine +12

Frequencies of independent and simultaneous selection of Chinese hamster cells for methotrexate and doxorubicin (adriamycin) resistance.

Glenn C. Rice, Victor Ling, Robert Schimke

Proceedings of the National Academy of Sciences

Drug Resistance AnalysisOncologySimultaneous SelectionTumor MicroenvironmentChemoprevention Strategy +11