Robert Schimke

Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells.

Glenn C. Rice, Cheryl Sew Hoy, Robert Schimke · Proceedings of the National Academy of Sciences · 1986 · 254 citations

Gene Amplification, Genetics, Pathology +20

Overreplication and recombination of DNA in higher eukaryotes: potential consequences and biological implications.

Robert Schimke, Steven W. Sherwood, Anna B. Hill et al. · Proceedings of the National Academy of Sciences · 1986 · 243 citations · Full text

Biological Implications, Dna Damage, Higher Eukaryotes +21

Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica.

Jeffrey A. Coderre, Stephen M. Beverley, Robert Schimke et al. · Proceedings of the National Academy of Sciences · 1983 · 240 citations · Full text

Gene Amplification, Biosynthesis, Engineering +13

Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells.

Bruce J. Dolnick, Ronald Berenson, Joseph R. Bertino et al. · The Journal of Cell Biology · 1979 · 184 citations · Full text

Gene Amplification, L5178y Cells, Cytogenetics +23

Cytotoxic effects of cell cycle phase specific agents: result of cell cycle perturbation.

Andrew L. Kung, A. Zetterberg, Steven W. Sherwood et al. · PubMed · 1990 · 144 citations

Apoptosis, Cell Death, Cellular Pharmacology +17