Joseph M. Perchiacca

Structure-based design of conformation- and sequence-specific antibodies against amyloid β

Joseph M. Perchiacca, Ali Reza A. Ladiwala, Moumita Bhattacharya et al. · Proceedings of the National Academy of Sciences · 2011 · 133 citations

Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions

Joseph M. Perchiacca, Ali Reza A. Ladiwala, M. Bhattacharya et al. · Protein Engineering Design and Selection · 2012 · 106 citations · Full text

Rational design of potent domain antibody inhibitors of amyloid fibril assembly

Ali Reza A. Ladiwala, Moumita Bhattacharya, Joseph M. Perchiacca et al. · Proceedings of the National Academy of Sciences · 2012 · 104 citations · Full text

Mutational analysis of domain antibodies reveals aggregation hotspots within and near the complementarity determining regions

Joseph M. Perchiacca, Moumita Bhattacharya, Peter M. Tessier · Proteins Structure Function and Bioinformatics · 2011 · 99 citations

Immunocytochemical Technique, Genetics, Immunology +25

Optimal charged mutations in the complementarity-determining regions that prevent domain antibody aggregation are dependent on the antibody scaffold

Joseph M. Perchiacca, C. C. Lee, Peter M. Tessier · Protein Engineering Design and Selection · 2014 · 61 citations · Full text

Immunocytochemical Technique, Peptide Engineering, Immunology +20