Direct activation of a bacterial innate immune system by a viral capsid protein

Tong Zhang, Hedvig Tamman, Kyo Coppieters ’t Wallant, +11

Nature

RelA-SpoT Homolog toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis

Tatsuaki Kurata, Tetiana Brodiazhenko, Sofia Raquel Alves Oliveira, +14

Molecular Cell

A nucleotide-switch mechanism mediates opposing catalytic activities of Rel enzymes

Hedvig Tamman, Katleen Van Nerom, Hiraku Takada, +8

Nature Chemical Biology

Cellular EnzymologyBiochemistryRel EnzymesNatural SciencesEnzyme Catalysis +3

(p)ppGpp controls stringent factors by exploiting antagonistic allosteric coupling between catalytic domains

Mohammad Roghanian, Katleen Van Nerom, Hiraku Takada, +9

Molecular Cell

A Moderate Toxin, GraT, Modulates Growth Rate and Stress Tolerance of Pseudomonas putida

Hedvig Tamman, Andres Ainelo, Kadi Ainsaar, +1

Journal of Bacteriology

ToxinologyGeneticsBacteriologyMolecular BiologyGrata Operon Structure +18

A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT

Ariel Talavera, Hedvig Tamman, Andres Ainelo, +6

Nature Communications

Chromosomal toxin-antitoxin systems in Pseudomonas putida are rather selfish than beneficial

Sirli Rosendahl, Hedvig Tamman, Age Brauer, +2

Scientific Reports

The TonB_m-PocAB System Is Required for Maintenance of Membrane Integrity and Polar Position of Flagella in Pseudomonas putida

Kadi Ainsaar, Hedvig Tamman, Sergo Kasvandik, +2

Journal of Bacteriology

The toxin GraT inhibits ribosome biogenesis

Andres Ainelo, Hedvig Tamman, Margus Leppik, +2

Molecular Microbiology

Microbial ToxinToxinologyRelated ToxinsToxin GratNatural Sciences +11

Structure of SpoT reveals evolutionary tuning of catalysis via conformational constraint

Hedvig Tamman, Karin Ernits, Mohammad Roghanian, +14

Nature Chemical Biology

Crystal StructureMolecular BiologyChemistryProtein SynthesisPpgpp Hydrolysis +15