Revealing the Activity of Trimeric G-proteins in Live Cells with a Versatile Biosensor Design

Marcin Maziarz, Jong‐Chan Park, Anthony Leyme, +4

Cell

Live CellsProtein FunctionBiochemistryBiomolecular ToolNatural Sciences +11

Protein Kinase A Contributes to the Negative Control of Snf1 Protein Kinase in Saccharomyces cerevisiae

LaKisha Barrett, Marianna Orlova, Marcin Maziarz, +1

Eukaryotic Cell

Molecular RegulationGeneticsSnf1 Protein KinaseMolecular BiologySignaling Pathway +17

Direct interrogation of context-dependent GPCR activity with a universal biosensor platform

Remi Janicot, Marcin Maziarz, Jong‐Chan Park, +8

Cell

EngineeringBiosensing SystemsBiomedical DiagnosticsBioanalysisMass Spectrometry +11

Atypical activation of the G protein Gαq by the oncogenic mutation Q209P

Marcin Maziarz, Anthony Leyme, Arthur Marivin, +5

Journal of Biological Chemistry

Naturally occurring hotspot cancer mutations in Gα13 promote oncogenic signaling

Marcin Maziarz, Anthony Federico, Jingyi Zhao, +5

Journal of Biological Chemistry

Probing the mutational landscape of regulators of G protein signaling proteins in cancer

Vincent DiGiacomo, Marcin Maziarz, Alex Luebbers, +3

Science Signaling

EngineeringGeneticsCancer BiologyTumor BiologyTumor Heterogeneity +19

Specific inhibition of GPCR-independent G protein signaling by a rationally engineered protein

Anthony Leyme, Arthur Marivin, Marcin Maziarz, +8

Proceedings of the National Academy of Sciences

A biochemical and genetic discovery pipeline identifies PLCδ4b as a nonreceptor activator of heterotrimeric G-proteins

Marcin Maziarz, Stefan Broselid, Vincent DiGiacomo, +6

Journal of Biological Chemistry

Optogenetic activation of heterotrimeric G-proteins by LOV2GIVe, a rationally engineered modular protein

Mikel Garcia‐Marcos, Kshitij Parag‐Sharma, Arthur Marivin, +3

eLife

EngineeringProtein AssemblyOptogenetic ActivationMolecular BiologyOptogenetics +22

DAPLE protein inhibits nucleotide exchange on Gαs and Gαq via the same motif that activates Gαi

Arthur Marivin, Marcin Maziarz, Jingyi Zhao, +8

Journal of Biological Chemistry