Matthew J. Simmons

Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis

Justine E. Roderick, Nicole Hermance, Matija Zelic et al. · Proceedings of the National Academy of Sciences · 2014 · 100 citations

Life Sciences, Cell Biology, Pathobiology +17

NF-κB-Dependent Assembly of an Enhanceosome-Like Complex on the Promoter Region of Apoptosis Inhibitor Bfl-1/A1

Leonard C. Edelstein, Lynn Lagos, Matthew J. Simmons et al. · Molecular and Cellular Biology · 2003 · 87 citations

Life Sciences, Cell Biology, Molecular Biology +13

Bfl-1/A1 functions, similar to Mcl-1, as a selective tBid and Bak antagonist

Matthew J. Simmons, Gaofeng Fan, W-X Zong et al. · Oncogene · 2007 · 73 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +10

Constitutive proteasome-mediated turnover of Bfl-1/A1 and its processing in response to TNF receptor activation in FL5.12 pro-B cells convert it into a prodeath factor

Jérôme Kucharczak, Matthew J. Simmons, Colin S. Duckett et al. · Cell Death and Differentiation · 2005 · 68 citations

Life Sciences, Biochemistry, Immunology +11

NOTCH1 inhibition in vivo results in mammary tumor regression and reduced mammary tumorsphere-forming activity in vitro

Matthew J. Simmons, Ryan W. Serra, Nicole Hermance et al. · Breast Cancer Research · 2012 · 57 citations · Full text

Medicine, Cell Biology, Oncology +17