Platelet Expression Profiling and Clinical Validation of Myeloid-Related Protein-14 as a Novel Determinant of Cardiovascular Events

Aileen M. Healy, Michael D. Pickard, Aruna D. Pradhan, +14

Circulation

A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state.

Hartmut Weiler-Guettler, Patricia D. Christie, David Beeler, +5

Journal of Clinical Investigation

ImmunologyThrombin ProductionTargeted Point MutationThrombosisHematology +16

Reversal of Disease-Related Pathologies in the Fragile X Mouse Model by Selective Activation of GABA_BReceptors with Arbaclofen

Christina Henderson, Lasani S. Wijetunge, Mika Kinoshita, +13

Science Translational Medicine

Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system.

Aileen M. Healy, Helen Rayburn, Robert Rosenberg, +1

Proceedings of the National Academy of Sciences

Embryos DieEmbryonic LethalityGeneticsTm DeficiencyEpigenetics +23

Myeloid-related protein 8/14 and the risk of cardiovascular death or myocardial infarction after an acute coronary syndrome in the Pravastatin or Atorvastatin Evaluation and Infection Theraphy: Thrombolysis in Myocardial Infarction (PROVE IT-TIMI 22) trial

David A. Morrow, Yunmei Wang, Kevin Croce, +11

American Heart Journal

ThrombosisMyeloid-related Protein 8/14Cardiovascular DiseaseCardiovascular DeathHematology +9

VEGF is deposited in the subepithelial matrix at the leading edge of branching airways and stimulates neovascularization in the murine embryonic lung

Aileen M. Healy, Laura Morgenthau, Xiahui Zhu, +2

Developmental Dynamics

Lung InflammationOrgan DevelopmentAngiogenesisTissue DevelopmentMatrix Biology +16

PKC-θ-Deficient Mice Are Protected from Th1-Dependent Antigen-Induced Arthritis

Aileen M. Healy, Elena S. Izmailova, Michael Fitzgerald, +10

The Journal of Immunology

ImmunologyImmune RegulationPathologyMusculoskeletal ResearchInflammatory Arthritis +15

Mice deficient in PKC theta demonstrate impaired<i>in vivo</i>T cell activation and protection from T cell-mediated inflammatory diseases

Karen S. Anderson, Michael Fitzgerald, Michelle DuPont, +9

Autoimmunity

Adaptive Immune SystemT-regulatory CellImmune RegulationImmunologyImmunologic Mechanism +22

Intravascular Coagulation Activation in a Murine Model of Thrombomodulin Deficiency: Effects of Lesion Size, Age, and Hypoxia on Fibrin Deposition

Aileen M. Healy, Wayne W. Hancock, Patricia D. Christie, +2

Blood

Gas 6 promotes Axl-mediated survival in pulmonary endothelial cells

Aileen M. Healy, John J. Schwartz, Xiahui Zhu, +3

American Journal of Physiology-Lung Cellular and Molecular Physiology

Gas 6Lung InflammationImmunologyCell DeathCellular Physiology +16