Neuroinflammatory phenotype in early Alzheimer's disease

Tiffany L. Sudduth, Frederick A. Schmitt, Peter T. Nelson, +1

Neurobiology of Aging

Alzheimer's DiseaseDementiaEarly AlzheimerVascular DementiaNeurochemical Biomarkers +4

Induction of Hyperhomocysteinemia Models Vascular Dementia by Induction of Cerebral Microhemorrhages and Neuroinflammation

Tiffany L. Sudduth, David K. Powell, Charles D. Smith, +2

Journal of Cerebral Blood Flow & Metabolism

AgingCerebral HemorrhageNeurochemical BiomarkersCerebral Vascular RegulationGeriatric Neurology +23

Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition

Brittani R. Price, Tiffany L. Sudduth, Erica M. Weekman, +4

Journal of Neuroinflammation

Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease

Donna M. Wilcock, Jennifer Hurban, Alex M. Helman, +8

Neurobiology of Aging

Down SyndromeNeurodegenerative DiseasesAlzheimer's DiseaseDistinct Neuroinflammatory PhenotypeDementia +9

Determining the role of IL-4 induced neuroinflammation in microglial activity and amyloid-β using BV2 microglial cells and APP/PS1 transgenic mice

Clare Latta, Tiffany L. Sudduth, Erica M. Weekman, +7

Journal of Neuroinflammation

Time-course of glial changes in the hyperhomocysteinemia model of vascular cognitive impairment and dementia (VCID)

Tiffany L. Sudduth, Erica M. Weekman, Brittani R. Price, +4

Neuroscience

Alzheimer's DiseaseAgingVascular Cognitive DisorderDementiaVascular Cognitive Impairment +9

Water exchange rate across the blood‐brain barrier is associated with CSF amyloid‐β 42 in healthy older adults

Brian T. Gold, Xingfeng Shao, Tiffany L. Sudduth, +4

Alzheimer s & Dementia

Intracranial Injection of Gammagard, a Human IVIg, Modulates the Inflammatory Response of the Brain and Lowers A  in APP/PS1 Mice Along a Different Time Course than Anti-A  Antibodies

Tiffany L. Sudduth, Alexander J. Greenstein, Donna M. Wilcock

Journal of Neuroscience

App/ps1 MiceM2a Inflammatory PhenotypeImmunologyImmunotherapySocial Sciences +20

β-amyloid deposition is shifted to the vasculature and memory impairment is exacerbated when hyperhomocysteinemia is induced in APP/PS1 transgenic mice

Tiffany L. Sudduth, Erica M. Weekman, Holly M. Brothers, +2

Alzheimer s Research & Therapy

Transition from an M1 to a mixed neuroinflammatory phenotype increases amyloid deposition in APP/PS1 transgenic mice

Erica M. Weekman, Tiffany L. Sudduth, Erin L. Abner, +6

Journal of Neuroinflammation