Merkel Polyomavirus-Specific T Cells Fluctuate with Merkel Cell Carcinoma Burden and Express Therapeutically Targetable PD-1 and Tim-3 Exhaustion Markers

Olga K. Afanasiev, Lola Yelistratova, Natalie J. Miller, +6

Clinical Cancer Research

ImmunologyImmune RegulationPathologyImmunodominanceImmunoediting +19

Systemic Immune Suppression Predicts Diminished Merkel Cell Carcinoma–Specific Survival Independent of Stage

Kelly G. Paulson, Jayasri G. Iyer, Astrid Blom, +8

Journal of Investigative Dermatology

Tumor ImmunologyCancer ImmunosurveillanceImmune Cell DevelopmentMedicineImmunology +11

Merkel Cell Polyomavirus-Specific CD8+ and CD4+ T-cell Responses Identified in Merkel Cell Carcinomas and Blood

Jayasri G. Iyer, Olga K. Afanasiev, Christopher L. McClurkan, +13

Clinical Cancer Research

Downregulation of MHC-I Expression Is Prevalent but Reversible in Merkel Cell Carcinoma

Kelly G. Paulson, Andrew Tegeder, Christoph Willmes, +18

Cancer Immunology Research

Mcc Cell LinesImmunologyImmunoeditingPathologyAntigen Processing +14

Vascular E-Selectin Expression Correlates with CD8 Lymphocyte Infiltration and Improved Outcome in Merkel Cell Carcinoma

Olga K. Afanasiev, Kotaro Nagase, William Simonson, +5

Journal of Investigative Dermatology

p63 Expression in Merkel Cell Carcinoma Predicts Poorer Survival yet May Have Limited Clinical Utility

Galina Y. Stetsenko, Jacqueline Malekirad, Kelly G. Paulson, +7

American Journal of Clinical Pathology

Anti-PD-1 antibody monotherapy versus anti-PD-1 plus anti-CTLA-4 combination therapy as first-line immunotherapy in unresectable or metastatic mucosal melanoma: a retrospective, multicenter study of 329 Japanese cases (JMAC study)

Yasuhiro Nakamura, Kenjiro Namikawa, Shusuke Yoshikawa, +28

ESMO Open

Real-world efficacy of anti-PD-1 antibody or combined anti-PD-1 plus anti-CTLA-4 antibodies, with or without radiotherapy, in advanced mucosal melanoma patients: A retrospective, multicenter study

Yoshiyasu Umeda, Shusuke Yoshikawa, Yukiko Kiniwa, +24

European Journal of Cancer

Cancer ImmunosurveillanceAnti-ctla-4 AntibodiesMedicineMelanomaImmunology +8

Efficacy comparison between anti-PD-1 antibody monotherapy and anti-PD-1 plus anti-CTLA-4 combination therapy as first-line immunotherapy for advanced acral melanoma: A retrospective, multicenter study of 254 Japanese patients

Yasuhiro Nakamura, Kenjiro Namikawa, Yukiko Kiniwa, +24

European Journal of Cancer

Advanced Acral MelanomaEfficacy ComparisonMedicineMelanomaImmunology +7

Effector Regulatory T Cells Reflect the Equilibrium between Antitumor Immunity and Autoimmunity in Adult T-cell Leukemia

Hiroshi Ureshino, Takero Shindo, Hiroyoshi Nishikawa, +15

Cancer Immunology Research