Endothelial cell ferroptosis mediates monocrotaline-induced pulmonary hypertension in rats by modulating NLRP3 inflammasome activation

Shanshan Xie, Yan Deng, Shenglan Guo, +5

Scientific Reports

BHBA Suppresses LPS-Induced Inflammation in BV-2 Cells by Inhibiting NF-<i>κ</i>B Activation

Shoupeng Fu, Sunan Li, Jianfa Wang, +10

Mediators of Inflammation

microRNA-421-3p prevents inflammatory response in cerebral ischemia/reperfusion injury through targeting m6A Reader YTHDF1 to inhibit p65 mRNA translation

Linbo Zheng, Xialin Tang, Minyi Lu, +4

International Immunopharmacology

ImmunologyCell DeathNeuroinflammationInflammationM6a Reader Ythdf1 +14

Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma

Fangzhou Liu, Tian Tian, Zhen Zhang, +18

Nature Metabolism

Mtorc1 ActivationMolecular BiologyLong Non-coding RnaMedicineCell Biology +4

Expansion of Tumor-reactive T Cells From Patients With Pancreatic Cancer

Qingda Meng, Zhenjiang Liu, Elena Rangelova, +10

Journal of Immunotherapy

Empirical identification and validation of tumor-targeting T cell receptors from circulation using autologous pancreatic tumor organoids

Qingda Meng, Shanshan Xie, G. Kenneth Gray, +12

Journal for ImmunoTherapy of Cancer

Discovery of Novel Potent Covalent Glutathione Peroxidase 4 Inhibitors as Highly Selective Ferroptosis Inducers for the Treatment of Triple-Negative Breast Cancer

Tingting Chen, Jiafu Leng, Jun Tan, +8

Journal of Medicinal Chemistry

Blocking the NLRP3 inflammasome reduces osteogenic calcification and M1 macrophage polarization in a mouse model of calcified aortic valve stenosis

Jing Lü, Shanshan Xie, Yan Deng, +2

Atherosclerosis

Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis

Yi Lu, Shanshan Xie, Wen Zhang, +13

Cell Research

Structural insights into ligand recognition and activation of the melanocortin-4 receptor

Huibing Zhang, Li-Nan Chen, Dehua Yang, +14

Cell Research

Systems BiologySignal TransductionMelanocortin-4 ReceptorStructural InsightsEngineering +10