Antimalarial efficacy of MMV390048, an inhibitor of <i>Plasmodium</i> phosphatidylinositol 4-kinase

Tanya Paquet, Claire Le Manach, Diego González Cabrera, +49

Science Translational Medicine

Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain

Idan Chiyanzu, Elizabeth Hansell, Jiří Gut, +3

Bioorganic & Medicinal Chemistry Letters

Thiosemicarbazone DerivativesMedicinal ChemistryBioorganic ChemistryBiochemistryNatural Sciences +6

Synthesis and antiplasmodial activity in vitro of new ferrocene–chloroquine analogues

Paul Beagley, Margaret Blackie, Kelly Chibale, +5

Dalton Transactions

X-ray CrystalBioorganic ChemistryEngineeringBiochemistryNatural Sciences +12

Quinoline–Pyrimidine Hybrids: Synthesis, Antiplasmodial Activity, SAR, and Mode of Action Studies

Kamaljit Singh, Hardeep Kaur, Peter Smith, +3

Journal of Medicinal Chemistry

Bioorganic ChemistryAction StudiesAntiparasitic AgentMalariaOrganic Chemistry +17

The synthesis and antiparasitic activity of aryl- and ferrocenyl-derived thiosemicarbazone ruthenium(ii)–arene complexes

Muneebah Adams, Yiqun Li, Heena Khot, +5

Dalton Transactions

Cyclopalladated complexes containing tridentate thiosemicarbazone ligands of biological significance: Synthesis, structure and antimalarial activity

Prinessa Chellan, Shereen Nasser, Livia Vivas, +2

Journal of Organometallic Chemistry

HeterocyclicBiochemistryMedicineAntimalarial ActivityBiological Significance +4

Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box

Janette Reader, Mariëtte van der Watt, Dale Taylor, +30

Nature Communications

Exploring the Versatility of Cycloplatinated Thiosemicarbazones as Antitumor and Antiparasitic Agents

Prinessa Chellan, Kirkwood M. Land, Ajit Shokar, +8

Organometallics

Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity

Manu Vanaerschot, James M. Murithi, Charisse Flerida A. Pasaje, +27

Cell chemical biology

Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery

James M. Murithi, Edward Owen, Eva S. Istvan, +7

Cell chemical biology