Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR

David Zemmour, Rapolas Žilionis, Evgeny Kiner, +3

Nature Immunology

Single-cell Gene ExpressionSingle Cell SequencingMedicineT-regulatory CellImmunology +9

The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments

Ricardo Grieshaber‐Bouyer, Felix A. Radtke, Pierre Cunin, +88

Nature Communications

Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas

Zohreh Amoozgar, Jonas Kloepper, Jun Ren, +19

Nature Communications

Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes

Evgeny Kiner, Elijah Willie, Brinda Vijaykumar, +95

Nature Immunology

Mucosal ImmunologyTh ArchetypesT-regulatory CellPathogenesisImmunology +5

The PARP1 inhibitor BMN 673 exhibits immunoregulatory effects in a Brca1 −/− murine model of ovarian cancer

Jing Huang, Lei Wang, Zhongyi Cong, +6

Biochemical and Biophysical Research Communications

MedicineImmunologyCancer Cell BiologyExhibits Immunoregulatory EffectsTumor Suppressor +5

Identification and validation of a tumor-infiltrating Treg transcriptional signature conserved across species and tumor types

Angela M. Magnuson, Evgeny Kiner, Ayla Ergün, +8

Proceedings of the National Academy of Sciences

Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8+ T cells

Kevin Wang, Paulina Coutifaris, David Brocks, +35

Cancer Cell

Cancer ImmunosurveillanceAutoimmune DiseaseT-regulatory CellImmunologyAutoimmunity +8

Efficient and specific gene knockdown by small interfering RNAs produced in bacteria

Linfeng Huang, Jingmin Jin, Padraig Deighan, +3

Nature Biotechnology

Effective methods for bulk RNA-seq deconvolution using scnRNA-seq transcriptomes

Francisco Avila Cobos, Mohammad Javad Najaf Panah, Jessica Epps, +15

Genome biology

Multi-clonal SARS-CoV-2 neutralization by antibodies isolated from severe COVID-19 convalescent donors

Michael Mor, Michal Werbner, Joel Alter, +25

PLoS Pathogens

Viral DiagnosticsVaccine TargetHumoral ResponseImmunologyRbd Inhibition +12