Manuel Colucci

Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis

Ilaria Guccini, Ajinkya Revandkar, Mariantonietta D’Ambrosio et al. · Cancer Cell · 2020 · 176 citations · Full text

Medicine, Molecular Biology, Oncology +10

Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer

Martina Troiani, Manuel Colucci, Mariantonietta D’Ambrosio et al. · Nature Communications · 2022 · 117 citations · Full text

Medicine, Cell Biology, Oncology +17

Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice

Sara Zumerle, Miles Sarill, Miriam Saponaro et al. · Nature Aging · 2024 · 90 citations · Full text

Education, Molecular Medicine, Pharmacology +17

Retinoic acid receptor activation reprograms senescence response and enhances anti-tumor activity of natural killer cells

Manuel Colucci, Sara Zumerle, Silvia Bressan et al. · Cancer Cell · 2024 · 67 citations · Full text

Medicine, Oncology, Pharmacology +15

The Akt/mTOR and MNK/eIF4E pathways rewire the prostate cancer translatome to secrete HGF, SPP1 and BGN and recruit suppressive myeloid cells

Daniela Brina, Adele Ponzoni, Martina Troiani et al. · Nature Cancer · 2023 · 62 citations · Full text

Medicine, Molecular Biology, Oncology +16