Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

Inna Kuperstein, Kerensa Broersen, Iryna Benilova, +15

The EMBO Journal

Neurodegenerative DiseasesAlzheimer's DiseaseDisease AβSmall ChangesDegenerative Pathology +8

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

Lucía Chávez‐Gutiérrez, Leen Bammens, Iryna Benilova, +15

The EMBO Journal

Neurodegenerative Diseasesγ-Secretase DysfunctionAlzheimer's DiseaseDegenerative PathologyNeurology +4

Structural Basis for Increased Toxicity of Pathological Aβ42:Aβ40 Ratios in Alzheimer Disease

Kris Pauwels, Thomas L. Williams, Kyle L. Morris, +8

Journal of Biological Chemistry

The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation?

Kerensa Broersen, Frédéric Rousseau, Joost Schymkowitz

Alzheimer s Research & Therapy

Peptide EngineeringMolecular BiologyNeurochemical BiomarkersOligomeric AggregatesPeptide Conformation +18

A standardized and biocompatible preparation of aggregate-free amyloid beta peptide for biophysical and biological studies of Alzheimer's disease

Kerensa Broersen, Wim Jonckheere, Jef Rozenski, +5

Protein Engineering Design and Selection

Peptide EngineeringNeurochemical BiomarkersPeptide ScienceBiocompatible PreparationSequential Solubilization +16

Amyloid precursor protein mutation E682K at the alternative β‐secretase cleavage β′‐site increases Aβ generation

Lujia Zhou, Nathalie Brouwers, Iryna Benilova, +11

EMBO Molecular Medicine

Glycoforms of β‐lactoglobulin with improved thermostability and preserved structural packing

Kerensa Broersen, Alphons G. J. Voragen, R.J. Hamer, +1

Biotechnology and Bioengineering

α-Synuclein Adopts an α-Helical Conformation in the Presence of Polyunsaturated Fatty Acids To Hinder Micelle Formation

Kerensa Broersen, Daan M. van den Brink, Graham Fraser, +2

Biochemistry

Proteinlipid InteractionHinder Micelle FormationAlpha-synuclein Aggregationα-Helical ConformationOxidative Stress +15

Mechanism of arachidonic acid action on syntaxin–Munc18

Emma Connell, Frédéric Darios, Kerensa Broersen, +4

EMBO Reports

Molecular PhysiologySignal TransductionBiochemistryMechanism Of ActionBiochemical Interaction +2

Optimized Triton X-114 assisted lipopolysaccharide (LPS) removal method reveals the immunomodulatory effect of food proteins

Małgorzata Teodorowicz, Olaf Perdijk, Iris C. Verhoek, +5

PLoS ONE