Downregulation of transcription factor Oct4 induces an epithelial-to-mesenchymal transition via enhancement of Ca2+ influx in breast cancer cells

Jiajia Hu, Kunhua Qin, Yan Zhang, +5

Biochemical and Biophysical Research Communications

Ca2+ InfluxDevelopmental BiologySignaling PathwayCell RegulationMedicine +10

Efficient engineering of human and mouse primary cells using peptide-assisted genome editing

Zhen Zhang, Amy E. Baxter, Diqiu Ren, +12

Nature Biotechnology

EngineeringGenome SurgeryMedicinePeptide EngineeringGenetic Engineering +11

ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression

Xianjiang Lan, Ren Ren, Ruopeng Feng, +17

Molecular Cell

Molecular PhysiologySignal TransductionZnf410 UniquelyMolecular BiologyHeme Signaling +5

The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression

Peng Huang, Scott A. Peslak, Xianjiang Lan, +10

Blood

SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice

Kunhua Qin, Ning Zhang, Zhao Zhang, +6

Diabetologia

Transcriptional RegulationSignal TransductionSignaling PathwayCell RegulationGene Expression +6

HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription

Peng Huang, Scott A. Peslak, Ren Ren, +15

Nature Genetics

Bcl11a TranscriptionTranscriptional RegulationDevelopmental BiologyHeme SignalingGene Expression +1

Inhibition of JMJD6 expression reduces the proliferation, migration and invasion of neuroglioma stem cells

Dan Zhou, Dong‐Ni Zhou, Song Zhan, +4

Neoplasma

Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells

Kunhua Qin, Peng Huang, Ruopeng Feng, +14

Nature Genetics

Adult Erythroid CellsDevelopmental BiologyHematologyBlood CellHeme Signaling +6

Overexpression of Oct4 suppresses the metastatic potential of breast cancer cells via Rnd1 downregulation

Long Shen, Kunhua Qin, Dekun Wang, +6

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Breast OncologyMedicineBreast Cancer CellsCancer Cell BiologyMetastatic Potential +7

Negative Elongation Factor Controls Energy Homeostasis in Cardiomyocytes

Haihui Pan, Kunhua Qin, Zhanyong Guo, +14

Cell Reports