Isaac Sappington

De novo design of protein structure and function with RFdiffusion

Joseph L. Watson, David Juergens, Nathaniel R. Bennett et al. · Nature · 2023 · 2K citations · Full text

Engineering, Bioinformatics, Biology +15

Broadly applicable and accurate protein design by integrating structure prediction networks and diffusion generative models

Joseph L. Watson, David Juergens, Nathaniel R. Bennett et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2022 · 148 citations · Full text

Life Sciences, Bioinformatics, Computational Biology +15

De novo designed proteins neutralize lethal snake venom toxins

Susana Vázquez Torres, Melisa Bénard-Valle, Stephen P. Mackessy et al. · Nature · 2025 · 133 citations · Full text

Life Sciences, Biotechnology, Pharmacology +17

Designed endocytosis-inducing proteins degrade targets and amplify signals

Buwei Huang, Mohamad H. Abedi, Green Ahn et al. · Nature · 2024 · 122 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

Mannose-binding lectin and complement mediate follicular localization and enhanced immunogenicity of diverse protein nanoparticle immunogens

Benjamin J. Read, Lori Won, John C. Kraft et al. · Cell Reports · 2022 · 60 citations · Full text

Life Sciences, Immunology, Molecular Biology +17