A Membrane Transporter Is Required for Steroid Hormone Uptake in Drosophila

Naoki Okamoto, Raghuvir Viswanatha, Riyan Bittar, +4

Developmental Cell

BiologyMembrane TransporterMolecular PhysiologyMembrane TransportPhysiology +9

Calorie restriction-induced SIRT6 activation delays aging by suppressing NF-κB signaling

Nannan Zhang, Zhongchi Li, Wei Mu, +6

Cell Cycle

Overexpressed SIRT6 attenuates cisplatin-induced acute kidney injury by inhibiting ERK1/2 signaling

Zhongchi Li, Kang Xu, Nannan Zhang, +6

Kidney International

InflammationReductive StressUrologyCell DeathAcute Kidney Injury +3

Pooled genome-wide CRISPR screening for basal and context-specific fitness gene essentiality in Drosophila cells

Raghuvir Viswanatha, Zhongchi Li, Yanhui Hu, +1

eLife

Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression

Zhongchi Li, Vivien Low, Valbona Luga, +15

Nature Communications

Suppression of nuclear GSK3 signaling promotes serine/one-carbon metabolism and confers metabolic vulnerability in lung cancer cells

Long He, Jennifer E. Endress, Sungyun Cho, +4

Science Advances

Serine SynthesisMolecular BiologySerine/one-carbon MetabolismMetabolic RemodelingCancer Biology +17

Protective Effects of SIRT6 Overexpression against DSS-Induced Colitis in Mice

Kang Xu, Yannan Guo, Ping Lu, +4

Cells

Sirtuin 6Chronic Inflammatory DiseasesImmunologyImmune RegulationPathology +18

Resveratrol Protects against High-Fat Diet Induced Renal Pathological Damage and Cell Senescence by Activating SIRT1

Nannan Zhang, Zhongchi Li, Kang Xu, +2

Biological and Pharmaceutical Bulletin

Lipid PeroxidationCell DeathCaloric RestrictionOxidative StressMetabolic Syndrome +20

Decreased Enterobacteriaceae translocation due to gut microbiota remodeling mediates the alleviation of premature aging by a high‐fat diet

Kang Xu, Yannan Guo, Yida Wang, +10

Aging Cell

A high‐fat diet reverses metabolic disorders and premature aging by modulating insulin and IGF1 signaling in SIRT6 knockout mice

Zhongchi Li, Kang Xu, Yannan Guo, +6

Aging Cell

Sirt6 DeficiencyMetabolic DisorderMetabolic DisordersCaloric RestrictionInsulin Signaling +14